Impact Factor:4.1
DOI number:10.1002/cctc.202301764
Journal:ChemCatChem
Abstract:The alkylation of arenes is one of the most fundamental transformations in synthetic chemistry and the transition-metal-catalyzed direct C−H alkylation represents a straightforward and attractive approach from both atom and step-economy perspectives. Epoxides, the smallest three-membered saturated O-heterocycles that can be easily prepared in racemic or enantioenriched forms, are highly useful building blocks for the synthesis of complex organic molecules. Owing to their inherent high ring-strain, epoxides readily undergo ring-opening reactions and have been used as alkylating reagents for C−H alkylation catalyzed by transition metals. This review summarizes recent advances in utilizing epoxides as alkylating reagents in transition-metal-catalyzed C−H alkylation as well as their synthetic applications in organic synthesis.
Indexed by:Journal paper
Discipline:Natural Science
Volume:16
Issue:14
Page Number:e202301764
ISSN No.:1867-3880
Translation or Not:no
Date of Publication:2024-07-22
Included Journals:SCI
Links to published journals:https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cctc.202301764
Date of Publication:2024-07-22