Impact Factor:9.8
DOI number:10.1007/s11426-022-1526-7
Journal:Science China-Chemistry
Abstract:We herein disclose a modular synthesis of 1-bromomethylene-THIQs involving a Catellani reaction of aryl iodides, aziridines, and terminal alkynes followed by an N-bromosuccinimide (NBS)-mediated cyclization. This approach features mild reaction conditions, wide substrate scope, good step-economy and good scalability. Based on this new method, we have accomplished the concise total synthesis of (±)-cularine, formal synthesis of 8-oxopseudopalmatine as well as the first total synthesis of dactyllactone A, demonstrating the wide synthetic potential of this method.
Discipline:Natural Science
Volume:11
Issue:66
Page Number:3136-3140
ISSN No.:1869-1870
Translation or Not:no
Included Journals:SCI
Links to published journals:https://link.springer.com/article/10.1007/s11426-022-1526-7#Sec1