熊军，博士，武汉大学公共卫生学院特聘副研究员，硕士研究生导师。2018年于武汉大学化学与分子科学学院获得博士学位（分析化学专业）。2018年至2023年在武汉大学从事博士后研究工作。2023年任武汉大学公共卫生学院特聘副研究员。研究方向主要围绕环境污染物暴露及核酸表观遗传修饰，结合队列研究及生物模型，探讨环境污染物的毒性效应和分子机制，探寻环境污染物与重大公共卫生健康问题的关联，筛查环境污染物暴露相关疾病的生物标志物。近年来发表SCI论文27余篇，其中以第一作者或（共同）通讯作者在Nucleic Acids Research、Chemical Science和Analytical Chemistry等学术期刊上发表SCI论文10余篇。获得国家自然科学青年基金资助，参与国家自然科学基金面上项目和湖北省技术创新计划重点研发专项等。
研究方向
环境毒理学、暴露组学、表观遗传学、代谢组学
主持与参与项目
1. 国家自然科学基金青年基金项目, 22207090, 基于人工进化胞嘧啶脱氨酶的DNA中5-甲基胞嘧啶和5-羟甲基胞嘧啶单碱基分辨率定位分析研究, 2023/01-2025/12, 主持。
2. 湖北省技术创新计划重点研发专项 （社会发展领域），妊娠期高血压的早期诊断与预测新技术新产品研发，2023/07-2025-12，项目骨干。
3. 国家自然科学基金面上项目, 21672166, 质谱探针技术研究重金属诱导的细胞表观遗传修饰动态变化及其机制, 2017/01-2020/12, 参与。
代表性研究论文
1. Xiong Jun,# Ye Tian-Tian,# Ma Cheng-Jie, Cheng Qing-Yun, Yuan Bi-Feng,* Feng Yu-Qi. N6-Hydroxymethyladenine: a hydroxylation derivative of N6-methyladenine in genomic DNA of mammals. Nucleic Acids Research, 2019, 47(3), 1268–1277.
2. Xiong Jun,# Wang Ping,# Shao Wen-Xuan, Li Gaojie, Ding Jiang-Hui, Xie Neng-Bin, Wang Min, Cheng Qing-Yun, Xie Conghua, Feng Yu-Qi, Ci Weimin,* Yuan Bi-Feng.* Genome-wide mapping of N4-methylcytosine at single-base resolution by APOBEC3A-mediated deamination sequencing. Chemical Science, 2022, 13, 9960–9972.
3. Jiang Han-Peng,# Xiong Jun,# Liu Fei-Long, Ma Cheng-Jie, Tang Xing-Lin, Yuan Bi-Feng,* Feng Yu-Qi. Modified nucleoside triphosphates exist in mammals. Chemical Science, 2018, 9(17), 4160–4167.
4. Xiong Jun,# Chen Ke-Ke,# Xie Neng-Bin, Ji Tong-Tong, Yu Si-Yu, Tang Feng, Xie Conghua, Feng Yu-Qi, Yuan Bi-Feng.* Bisulfite-free and single-base resolution detection of epigenetic DNA modification of 5-methylcytosine by methyltransferase-directed labelling with APOBEC3A deamination sequencing. Analytical Chemistry, 2022, 94, 15489-15498.
5. Xiong Jun,# Chen Ke-Ke,# Xie Neng-Bin,# Ji Tong-Tong, Yu Si-Yu, Tang Feng, Xie Conghua, Feng Yu-Qi, Yuan Bi-Feng.* Demethylase-assisted site-specific detection of N1-methyladenosine in RNA. Chinese Chemical Letters, 2023, doi: 10.1016/j.cclet.2023.108953.
6. Xiong Jun,# Jiang Han-Peng,# Peng Chun-Yan,# Deng Qian-Yun, Lan Meng-Dan, Zeng Huan, Zheng Fang, Feng Yu-Qi,* Yuan Bi-Feng.* DNA hydroxymethylation age of human blood determined by capillary hydrophilic-interaction liquid chromatography/mass spectrometry. Clinical Epigenetics, 2015, 7, 72.
7. Zhang Hao-Ying,# Xiong Jun,# Qi Bao-Ling, Feng Yu-Qi,* Yuan Bi-Feng.* The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals. Chemical Communications, 2016, 52(4), 737–740.
8. Cheng Qing-Yun,# Xiong Jun,# Huang Wei, Ma Qin, Ci Weimin, Feng Yu-Qi,* Yuan Bi-Feng.*Sensitive determination of onco-metabolites of D- and L-2-hydroxyglutarate enantiomers by chiral derivatization combined with liquid chromatography/mass spectrometry analysis. Scientific Reports, 2015, 5, 15217.
9. Xiong Jun,# Liu Xiaona,# Cheng Qing-Yun, Xiao Shan, Xia Lai-Xin,* Yuan Bi-Feng,* Feng Yu-Qi. Heavy metals induce decline of derivatives of 5-methycytosine in both DNA and RNA of stem cells. ACS Chemical Biology, 2017, 12(6), 1636–1643.
10. Xiong Jun, Yuan Bi-Feng,* Feng Yu-Qi. Mass spectrometry for investigating the effects of toxic metals on nucleic acid modifications. Chemical Research in Toxicology, 2019, 32(5), 808–819.
