宋恒
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宋恒，教授，博士生导师，国家海外高层次人才引进计划，武汉大学弘毅青年学者，湖北省高层次人才，“3551光谷人才计划”，研究方向化学生物学、合成生物学和酶催化。
教育与研究经历：
2018至今 教授、博导， 武汉大学化学与分子科学学院
2015 – 2018 博士后，劳伦斯伯克利国家实验室和加州大学伯克利分校
2010 – 2015 博士，波士顿大学化学系
2005 – 2009 学士，南京大学化学系
研究领域与兴趣：化学生物学、合成生物学、生物工程、酶催化、小分子探针在生物过程中的检测应用、蛋白工程改造、代谢工程生产、生物信息学和化学信息学。
获资助项目：
2025-深圳市自然科学基金面上项目
2025-国家发改委绿色生物制造项目
2024-广东省自然科学基金面上项目
2023-国家自然科学基金面上项目
2023-入选 湖北省高层次人才
2022-共同药业[股票300966]高级科学家顾问
2022-入选“3551光谷人才计划”
2022-广东省自然科学基金面上项目
2021-入选“南鄂英才计划”
2020-国家自然科学基金青年项目
2019-科技部重点研发计划纳米专项青年项目课题负责
2019-科技部重点研发计划合成生物学专项子课题负责
2018- 武汉大学引进人才项目， 国家海外高层次人才引进计划
欢迎有志于合成生物学和化学生物学以及生物工程方向的、致力于复合型学科研究的青年才俊前来交流、切磋和学习；欢迎参加武汉大学“优秀大学生暑期夏令营”的同学咨询宋老师实验室相关情况；欢迎优秀学子报考宋老师化学和生物学交叉方向实验室的推免研究生、博士生和研究生。
此外，因研究工作需要，实验室长期招募优秀的博士后研究员（年薪25-40万,上不封顶）和研究助理（年薪8万以上），享受武汉大学相关福利政策，待遇非常优厚，欢迎来信垂询。
课题组发表：
1. Tian Wang, Wenye Cao, Xuemei Wang，Min Dong, Lu Yu, Yinyin Feng, Ning Yang*, Heng Song*，Composite synthetic protein hydrogel for inhibition of corneal fibrosis and treatment of corneal wounds, International Journal of Biological Macromolecules, 2025, 3072, 142013.
2. Weihua Wang, Han Zhu, Bo Gu, Yongze Xie, Xinlei Xu, Shu-Lin Liu*, Heng Song*，Polarity Sensitive and H2O2/Lipid Droplets Sequence-Activated Asymmetric Cyanine Probe Achieves Multi-marker Imaging of Atherosclerosis，Chinese Journal of Chemistry, 2025, 43, 1246-1254.
3. Zhuo-Kun Chen, Shuo Zheng, Yan Long, Kui-Ming Wang, Bo-Lin Xiao, Jin-Bang Li, Wei Zhang*, Heng Song,* and Gang Chen*, High-throughput screening identifies ibuprofen as an sEV PD-L1 inhibitor for synergistic cancer immunotherapy, Molecular Therapy, 2024, 32, 3580-3596.
4. Shuo Zheng, Xinlei Xu, Tian Gao, and Heng Song*, One-Pot Microbial Cell Factory Strategy for the Production of Protocatechuic Acid from Polyethylene Terephthalate Waste, ACS Sustainable Chemistry&Engineering, 2024, 12, 5632-5639.
5. Weihua Wang, Chu Han, Shengjie Xie, Zisong Cong, Zixuan Yang, Yuxin Feng, Limin Xiang,and Heng Song*，A High-Contrast Autolysosome Probe for Detecting Interactionbetween Autophagosomes and Autolysosomes in Mitophagy, Chinese Journal of Chemistry, 2024, 42, 858-866.
6. Xinying Ge#, Yan Long#, Jun Wang#, Bo Gu, Zixuan Yang, Yinyin Feng, Shuo Zheng, Yingying Li, Wupeng Yan* and Heng Song*，Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy and protein engineering，Science China Chemistry, 2023, 66.
7. Shengbo Li, Xuemei Wang, Zhiyao Yan, Tian Wang, Zhenbing Chen, Heng Song* and Yongbin Zheng*, Microneedle Patches with Antimicrobial and Immunomodulating Properties for Infected Wound Healing, Advanced Science, 2023, 2300576.
8. Shengjie Xie, Zisong Cong, Weihua Wang, Shanshan Qin, Xiaocheng Weng*, Heng Song*, Xiang Zhou, Mitochondria-targeting NIR AIEgens with cationic amphiphilic chaacter for imaging and efficient photodynamic therapy, Chemical Communication, 2023, 59, 2592.
9. Zhiqin Xu, Yaling Mo, Zhengwen Li, Shurong Ban* and Heng Song*, New small-molecule alcohol synthesis by breaking the space limitation of the “aromatic cage”in Pseudomonas sp. AK1 BBOX, Organic Biomolecular Chemistry, 2023, 21, 6397–6404
10. Zhen Q. Wang#, Heng Song#(共同一作), Edward J. Koleski, Noritaka Hara, Dae Sung Park, Gaurav Kumar, Yejin Min, Paul J. Dauenhauer and Michelle C. Y. Chang*，A dual cellular–heterogeneous catalyst strategy for the production of olefins from glucose，Nature Chemistry, 2021, 13, 1178–1185.
11. Zhuoran Jiang, Chao Wang, Zixin Wu, Kun Chen, Wei Yang, Hexiang Deng*, Heng Song* and Xiang Zhou*, Enzymatic deamination of the epigenetic nucleoside N6-methyladenosine regulates gene expression, Nucleic Acids Research, 2021, 49, 12049-12069.
12. Yunbin Wu, Rui Xu, Yuxin Feng, Heng Song*, Rational Design of a De Novo Enzyme Cascade for Scalable Continuous Production of Antidepressant Prodrugs, ACS Catalysis, 2022, 12, 3767-3775.
13. Yan Long#, Shuo Zheng#, Yuxin Feng, Zixuan Yang, Xinlei Xu, and Heng Song*, Kinetic Solvent Isotope Effect in P450-Mediated Cyclization in Indolactams: Evidence for Branched Reactions and Guide for Their Modulation in Heterocycle Chemoenzymatic Synthesis, ACS Catalysis, 2022, 12, 9857-9863.
14. Xuemei Wang#, Shengbo Li#, Siqi Wang, Shuo Zheng, Zhenbing Chen*, Heng Song*, Protein Binding Nanoparticles as an Integrated Platform for Cancer Diagnosis and Treatment, Advanced Science, 2022, 2202453.
15. Zisong Cong#, Shengjie Xie#, Zhuoran Jiang, Shuo Zheng, Weihua Wang, Wenyan Wang and Heng Song*, In vivo photodynamic therapy based on Near-Infrared AIE cationic polymers, Chemical Engineering Journal, 2022, 431, 133748.
16. Jie Wang#, Zhuoran Jiang#, Yurong Wei#, Wenjie Wang, Fubing Wang, Yanbing Yang*, Heng Song*, and Quan Yuan*, Multiplexed identification of bacterial biofilm infections based on machine-learning-aided lanthanide encoding, ACS Nano, 2022, 16, 2, 3300–3310.
17. Wenyan Wang, Shuo Zheng, Yinhui Hong, Xinlei Xu, Xiang Feng, and Heng Song*, Hydrogel-metal-organic-framework nanoparticle composites for immobilization of active biomacromolecules, ACS Applied Nano Materials. 2022, 5, 2, 2222–2230.
18. Shengbo Li#, Xuemei Wang#, Jing Chen, Jiahe Guo, Meng Yuan, Gui Wan, Chengqi Yan, Wenqing Li, Hans-Günther Machens,Yuval Rinkevich, XiaofanYang*, Heng Song* and Zhenbing Chen*, Calcium ion cross-linked sodium alginate hydrogels containing deferoxamine and copper nanoparticles for diabetic wound healing, International Journal of Biological Macromolecules, 2022, 202, 657-670.
19. Yuxin Feng,# Yan Long,# Jiahe Guo,# Xiaofan Yang* and Heng Song*, Redox- and pH-responsive water-soluble flexible organic frameworks realize synergistic tumor photodynamic and chemotherapeutic therapy, Macromolecular Rapid Communications, 2022, DOI: 10.1002/marc.202200690.
20. Siqi Wang, Zisong Cong, Zhiqin Xu, Shurong Ban* and Heng Song*, Fluorescent dyes with multiple quaternary ammonium centers for specific image discrimination and Gram-positive antibacterial activity, Organic & Biomolecular Chemistry. 2022, 20, 3980-3987.
21. Yaxuan Qian#, Zhuoran Jiang#, Yan Long#, Houguo Fei, Heng Song*, Cunlan Guo*, Electro-Enzymatic Aromatic Nitration via Electric Field and Electro-mediator, ACS Sustainable Chemistry&Engineering, 2022, 10, 6667-6674.
邮箱 :
2005.9 -- 2009.7
南京大学
化学
学士
学士
2010.1 -- 2015.4
波士顿大学
化学生物学、合成生物学
博士
博士
武汉大学 化学与分子科学学院 教授、博士生导师
加州大学伯克利分校 化学学院 博士后
