王雅芬，博士，武汉大学公共卫生学院特聘副研究员。2018年毕业于武汉大学化学与分子科学学院，师从周翔院士，获得博士学位（有机化学专业）。2018年至2022年在武汉大学从事博士后研究工作（入选2018年“博士后创新人才支持计划”）。主要研究方向是围绕核酸表观遗传修饰，探讨环境毒理与重大疾病的关系，寻找人工干预的生物学毒性的途径，探讨疾病的致病机制。主持国家自然科学基金面上项目、青年项目、博士后创新人才支持计划和中国博士后科学基金面上项目。迄今发表SCI论文35余篇，其中以（共同）通讯作者或第一作者在Chemical Society Reviews，Accounts of Chemical Research，Nature Communications，Chemical Science，Analytical Chemistry等学术期刊发表SCI论文24篇。

主持的科研项目

1.  国家自然科学基金委面上项目，22377096，2024/1-2027/12，主持

2.  国家自然科学基金委青年基金项目，21907077，2020/1-2022/12，主持

3.  2018年度“博士后创新人才支持计划”（人力资源社会保障部和全国博士后管委会），BX201800225，2018/6-2020/6，主持

4.  第65批中国博士后科学基金面上项目，2019M652691，2019/5-2020/6，主持

5.  2018湖北省博士后科技活动项目择优资助，2018/11-2020/6，主持

代表性论文

1.  Yafen Wang* and Xiang Zhou, N⁶-methyladenosine and Its Implications in Viruses, Genomics, Proteomics & Bioinformatics, 2022, in press. 

2.  Yafen Wang, Wei Yang and Xiang Zhou*, Chemical labelling for m6A detection: opportunities and challenges, Fundamental Research, 2022, 2 (1), 56−58.

3.  Yafen Wang^#, Zonggui Chen^#, Xiong Zhang^#, Xiaocheng Weng^#, Jikai Deng^#,Wei Yang, Fan Wu, Shaoqing Han, Chao Xia, Yu Zhou, Yu Chen and Xiang Zhou*, Single-Base Resolution Mapping Reveals Distinct 5-Formylcytidine in  Saccharomyces cerevisiae mRNAs, ACS Chemical Biology, 2022, 17 (1), 77−84. (Front Cover)

4.  Yafen Wang^#, Shaoqing Han^#, Ruoxi Ran^#, Anling Li^#, Huanyu Liu, Mingjun Liu, Yongwei Duan, Xiong Zhang, Xiaocheng Weng*, Songmei Liu* and Xiang Zhou*, A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome, Nature Communications, 2021, 12:5629. (Editors’ Highlights)

5.  Yafen Wang^#, Xiong Zhang^#, Shaoqing Han^#, Wei Yang, Zonggui Chen, Fan Wu, Jizhou Liu, Xiaocheng Weng* and Xiang Zhou*, Base-Resolution Analysis of Deoxyuridine at Genome Scale Based on Artificial Incorporation Modified Nucleobase, ACS Central Science, 2021, 7 (6), 973−979. (Front Cover)

6.  Yafen Wang, Xiong Zhang, Hui Liu and Xiang Zhou*, Chemical Methods and Advanced Sequencing Technologies for Deciphering mRNA Modifications, Chemical Society Reviews, 2021, 50 (24), 13481–13497. 

7.  Jizhou Liu^#, Wei Yang^#, Xiong Zhang, Yafen Wang* and Xiang Zhou*, Bisulfite-free and quantitative detection of 5-formylcytosine in DNA through qPCR, Chemical Communications, 2021, 57 (100), 13796–13798.

8.  Wei Yang^#, Shaoqing Han^#, Xiong Zhang^#, Yafen Wang^#, Guangrong Zou, Chaoxing Liu, Muxin Xu, and Xiang Zhou*, Sequencing 5-formyluracil in genomic DNA at single-base resolution, Analytical Chemistry, 2021, 93 (46), 15445−15451.

9.  Hongmei Yang^#, Yafen Wang^#, Jing Tang, Fang Wang* and Zilin Chen*, End-labeling-based electrochemical strategy for detection of adenine methylation in nucleic acid by differential pulse voltammetry, Microchimica Acta, 2021, 188 (8):250.

10.  Yafen Wang, Xiong Zhang, Guangrong Zou, Shuang Peng, Chaoxing Liu and Xiang Zhou*, Detection and Application of 5-Formylcytosine and 5-Formyluracil in DNA, Accounts of Chemical Research, 2019, 52 (4), 1016−1024. (Supplementary Cover)

11.  Yafen Wang^#, Xiong Zhang^#, Fan Wu, Zonggui Chen and Xiang Zhou*, Bisulfite-free, single base-resolution analysis of 5-hydroxymethylcytosine in genomic DNA by chemical-mediated mismatch, Chemical Science, 2019, 10 (2), 447−452. 

12.  Xiong Zhang ^#, Yafen Wang ^# and Xiang Zhou*, A Ligation-Based qPCR Amplification Assay for the Radiolabeling-Free Detection of ATP/NAD+ with High Selectivity and Sensitivity, Analytical Chemistry, 2019, 91 (2),1665−1670.

13.  Yafen Wang ^#, Chaoxing Liu ^#, Fan Wu ^#, Xiong Zhang, Sheng Liu, Zonggui Chen, Weiwu Zeng, Wei Yang, Xiaolian Zhang, Yu Zhou, Xiaocheng Weng, Zhiguo Wu and Xiang Zhou*, Highly Selective 5-Formyluracil Labeling and Genome-wide Mapping Using (2-Benzimidazolyl)Acetonitrile Probe, iScience, 2018, 9, 423−432.

14.  Yafen Wang^#, Chaoxing Liu^#, Xiong Zhang^#, Wei Yang, Fan Wu, Guangrong Zou, Xiaocheng Weng* and Xiang Zhou*, Gene specific-loci quantitative and single-base resolution analysis of 5-formylcytosine by compound-mediated polymerase chain reaction, Chemical Science, 2018, 9 (15), 3723−3728. 

15.  Yafen Wang^#, Chaoxing Liu ^#, Wei Yang ^#, Guangrong Zou, Xiong Zhang, Fan Wu, Shuyi Yu, Xiaomeng Luo and Xiang Zhou*, Naphthalimide derivatives as multifunctional molecules for detecting 5-formylpyrimidine by both PAGE analysis and dot-blot assays, Chemical Communications, 2018, 54 (12), 1497−1500.

16.  Chaoxing Liu ^#, Yafen Wang ^#, Wei Yang, Fan Wu, Weiwu Zeng, Zonggui Chen, Jinguo Huang, Guangrong Zou, Xiong Zhang, Shaoru Wang, Xiaocheng Weng, Zhiguo Wu, Yu Zhou and Xiang Zhou*, Fluorogenic labeling and single-base resolution analysis of 5-formylcytosine in DNA, Chemical Science, 2017, 8 (11), 7443−7447.

17.  Chaoxing Liu ^#, Yafen Wang ^#, Xiong Zhang, Fan Wu, Wei Yang, Guangrong Zou, Qian Yao, Jiaqi Wang, Yuqi Chen, Shaoru Wang and Xiang Zhou*, Enrichment and fluorogenic labelling of 5-formyluracil in DNA, Chemical Science, 2017, 8 (6), 4505−4510.

18.  Chaoxing Liu ^#, Yuqi Chen ^#, Yafen Wang ^#, Fan Wu, Xiong Zhang, Wei Yang, Jiaqi Wang, Yi Chen, Zhiyong He, Guangrong Zou, Shaoru Wang, and Xiang Zhou*, A highly efficient fluorescence-based switch-on detection method of 5-formyluracil in DNA, Nano Research, 2017, 10 (7), 2449−2458. 

19.  Yafen Wang, Chaoxing Liu, Tianlu Wang, Tingting Hong, Haomiao Su, Shuyi Yu, Hongwei Song, Songmei Liu, Xin Zhou, Wuxiang Mao* and Xiang Zhou*, Highly Selective Detection of 5-Methylcytosine in Genomic DNA Based on Asymmetric PCR and Specific DNA Damaging Reagents, Analytical Chemistry, 2016, 88 (6), 3348−3353.