Research Interests:

The Xiang Lab's research focuses on the developments   of multi-dimensional and functional super-resolution imaging techniques to   resolve nanoscale heterogeneity for lives and nanomaterials. To achieve this goal, our lab mainly works on the following directions:

I. Developments of novel multi-dimensional super-resolution imaging technique to resolve functional information, including diffusivity, polarity, electrical potential, enzyme activity, ion concentration and so on.

II. Visualizations of nanoscale heterogeneity for intracellular   environments and nanomaterials to investigate the structure-function relationship at the single-molecule level.

III. Integration of multi-dimensional super-resolution imaging technique and electrochemical systems to unveil the interplay between electric and optical properties of single molecules, and explore how this interplay can affect biochemical activities at the nanoscale

Representative Publications:

1. L. Xiang†, K. Chen†, R. Yan, W. Li & K. Xu*, “Single-molecule displacement mapping unveils nanoscale heterogeneities in   intracellular diffusivity”. Nat. Methods 2020, 17, 524-530

2. L. Xiang, M. Wojcik, S. J. Kenny, R. Yan, S.   Moon, W. Li & K. Xu*, “Optical characterization of surface adlayers and   their compositional demixing at the nanoscale”. Nat. Commun. 2018, 9, 1435

3. L. Xiang*, R. Yan, K. Chen, W. Li, K. Xu*,   "Single-molecule displacement mapping unveils sign-asymmetric protein   charge effects on intraorganellar diffusion," Nano Lett. 2023, 23, 1711

4. L. Xiang†, K. Chen†, K. Xu*, “Single molecules   are your quanta: A bottom-up approach toward multidimensional   super-resolution microscopy”. ACS Nano   2021, 15, 12483-12496

5. R. Sha†, L. Xiang†, C. Liu†, A. Balaeff, Y.   Zhang, P. Zhang, Y. Li, D. N. Beratan*, N. Tao* & N. C. Seeman*, “Charge   splitters and charge transport junctions based on guanine quadruplexes”. Nat. Nanotech. 2018, 13, 316-321

6. L. Xiang, J. L. Palma, Y. Li, V. Mujica, M. A.   Ratner & N. Tao*, “Gate-controlled conductance switching in DNA”, Nat. Commun. 2017, 8, 14471

7. C. Liu†, L. Xiang†, Y. Zhang, P. Zhang, Y. Li, N.   Tao & D. N. Beratan*, “Engineering nanometer-scale coherence in soft   matter”, Nat. Chem. 2016, 8, 941-945

8. L. Xiang, J. L. Palma, C. Bruot, V. Mujica, M. A. Ratner & N. Tao*, “Intermediate tunnelling–hopping regime in DNA charge transport”, Nat. Chem. 2015, 7, 221-226