Profile

易红 武汉大学高等研究院特聘研究员，博士生导师。迄今， 以（共同）通讯作者发表学术论文30余篇，包括 Nature Chemistry 1篇, Nature Synthesis 1篇, Chem 1篇, Natl. Sci. Rev. 1篇, J. Am. Chem. Soc. 4篇, Angew. Chem. Int. Ed. 4篇, Nat. Commun. 3篇。主持国家自然科学基金青年科学基金项目B类（2025），国家重点研发计划“催化专项”青年科学家项目（2022）、湖北省省级技术创新项目（2025）。

学习与工作简历

2008.09-2012.06在武汉大学化学分子科学学院化学基地班学习；

2017.6博士毕业于武汉大学化学与分子科学学院，师从雷爱文教授；

2017.9-2019.11作为洪堡学者博士后在德国柏林工业大学进行研究，合作导师Martin Oestreich教授；

2020.01-2021.11作为JSPS研究员在名古屋大学工作，合作导师Cathleen M. Crudden教授。

2022.03 - 至今 武汉大学高等研究院特聘研究员、博士生导师

研究方向简介

聚焦复杂合成体系原位谱学与反应机制，利用多种原位谱学研究均相合成反应机制，解决合成化学中的瓶颈问题。主要研究方向：

（1）复杂体系原位谱学方法建立：开发并优化适用于复杂反应环境的原位谱学技术（包括光/电化学方法），实现对反应过程的实时、动态监测；

（2）合成化学活性中间体结构表征与性质：表征光/电合成反应中的关键活性中间体（如自由基、有机金属中间体、金属簇），解析其结构、稳定性及动态演变规律；

（3）有机合成反应机制与可视化应用：阐明合成反应中化学键活化、单电子转移及选择性转化的机制，并推动机制研究结果在反应优化与机理可视化中的应用。

代表性学术论文

1.       Shuxiang Zhu, Zhipeng Guan, Yanlong Liu, Heng Zhang,* Aiwen Lei,* and Hong Yi* Unveiling the Switchable Chemoselectivity Mechanism in Electrochemical Nickel-Catalyzed C(sp2)-O Coupling of Phenols and Aliphatic Alcohols J. Am. Chem. Soc. 2025, 147, 10.1021/jacs.5c07188.

2.             Haozhe Dong, Xuejie Wang, Pingsen Shi, Nian Chen, Zhiqiang Zhang, Jia Yan, Aiwen Lei* and Hong Yi* N-Heterocyclic Carbene-Ligated Mixed-valent Linear Cu₃ Cluster for Enhanced Electrocatalytic Nitrite Reduction. J. Am. Chem. Soc. 2025,147, 29423-29430.

3.             S. Liu, H. Lin, T. Peng, Z. Yang, P. Wan, J. Li, L. Yang, X. Dai, S. Tu, X. Long, A. Lei*, T. Wang*, H. Yi*. Electrochemical Amino‐Oxygenation Cyclization via Alkene Radical Cation/Bisnucleophile Engagement to Saturated N/O‐Heterocycles. Angew. Chem. Int. Ed. 2025, 64, e202501424.

4.            Demin RenYuan WangZhao LiuYatao WangWei DingFengze YaoXiaotian Qi* Aiwen Lei* Hong Yi* Cobaloxime-Catalyzed Radical Allylic C–H Sulfonylation Through Synergistic XAT/HAT Processes ACS Catal. 2025, 15, 13127–13135

5.             S. Wang, X. Luo, Y. Wang, Z. Liu, Y. Yu, X. Wang, D. Ren, P. Wang, Y. H. Chen, X. Qi*, H. Yi*, A. Lei*. Radical-triggered translocation of C-C double bond and functional group. Nat. Chem. 2024, 16, 1621-1629.

6.             J. Hu, H. He, M. Xu, X. Qi, C. Fu, H. Yi*, A. Lei*. Adduct-catalyzed tandem electro-thermal synthesis of organophosphorus (III) compounds from white phosphorus. Natl. Sci. Rev. 2025, 12, nwaf008.

7.             L. Nie, J. Yang, Z. Liu, S. Zhou, S. Chen, X. Qi,* A. Lei,* and H. Yi*. Linear Paired Electrolysis Enables Redox-Neutral (3 + 2) Annulation of Benzofuran with Vinyldiazo Compounds, J. Am. Chem. Soc. 2024, 146, 31330-31338.

8.             X. Liu, J. Chen, Z. Wei*, H. Yi*, A. Lei*. Deciphering reactive intermediates in electrooxidative coupling of indoles through real-time mass spectrometry. Chem. 2024, 10, 2131-2146.

9.             J. Zhang, Z. Yang*, C. Liu, H. Wan, Z. Hao, X. Ji, P. Wang,H. Yi*, A. Lei*. Tailoring photocatalysts to modulate oxidative potential of anilides enhances para-selective electrochemical hydroxylation. Nat. Commun. 2024, 15, 6954.

10.       X. Liu, D. Yang, Z. Liu, Y. Wang, Y. Liu, S. Wang, P. Wang, H. Cong, Y. H. Chen*, L. Lu*, X. Qi*,H. Yi*, A. Lei*. Unraveling the Structure and Reactivity Patterns of the Indole Radical Cation in Regioselective Electrochemical Oxidative Annulations. J. Am. Chem. Soc. 2023, 145, 3175-3186.

11.       X. Luo, D. Yang, X. He, S. Wang, D. Zhang, J. Xu, C. W. Pao, J. L. Chen, J. F. Lee, H. Cong, Y. Lan, H. Alhumade, J. Cossy*, R. Bai*, Y. H. Chen*, H. Yi*, A. Lei*. Valve turning towards on-cycle in cobalt-catalyzed Negishi-type cross-coupling. Nat. Commun. 2023, 14, 4638.

12.       D. Yang, Z. Guan, Y. Peng, S. Zhu, P. Wang, Z. Huang, H. Alhumade, D. Gu*, H. Yi*, A. Lei*. Electrochemical oxidative difunctionalization of diazo compounds with two different nucleophiles. Nat. Commun. 2023, 14, 1476.

13.       Z. Yang, W. Shi, H. Alhumade, H. Yi*, A. Lei*. Electrochemical oxidative C(sp³)–H cross-coupling with hydrogen evolution. Nat. Synth. 2023, 2, 217-230.

14.       Q. Wan, K. Chen, X. Dong, X. Ruan, H. Yi*, S. Chen*. Elucidating the Underlying Reactivities of Alternating Current Electrosynthesis by Time-Resolved Mapping of Short-Lived Reactive Intermediates. Angew. Chem. Int. Ed. 2023, 62, e202306460.

15.       L. Zeng, J. Wang, D. Wang, H. Yi*, A. Lei*. Comprehensive Comparisons between Directing and Alternating Current Electrolysis in Organic Synthesis. Angew. Chem. Int. Ed. 2023, 62, e202309620.

16.       K. Liang, D. Zhang, Y. Su, L. Lu, J. Hu, Y. H. Chen*, X. Zhang*, A. Lei*, H. Yi*. Fragile intermediate identification and reactivity elucidation in electrochemical oxidative alpha-C(sp³)-H functionalization of tertiary amines. Chem. Sci. 2023, 14, 4152-4157.