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    Female

  • Discipline:

    Analytical Chemistry

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    Employed

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    化学与分子科学学院

  • Education Level:

    研究生毕业

  • Alma Mater:

    武汉大学

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    Employed

  • School/Department:

    化学与分子科学学院

  • Discipline:

    1 Analytical Chemistry

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Paper Publications

Current position: Home > Scientific Research > Paper Publications

Preparation, characterization, and chromatographic evaluation of nickel oxide deposited silica stationary phase in hydrophilic interaction liquid chromatography

  • Time:2026-05-06
  • Hits:

  • DOI number:

    10.1007/s10337-023-04235-6

  • Journal:

    Chromatographia

  • Key Words:

    Coordination · Hydrophilic interaction liquid chromatography · Nickel oxide deposited silica · Stationary phase

  • Abstract:

    Nickel oxide deposited silica stationary phase was prepared by liquid phase deposition and characterized. Its chromatographic
    performance was evaluated using several compounds such as typical polar compounds and benzimidazoles as probes. The
    effects of mobile phase variables such as acetonitrile content, salt concentration, and pH on the chromatographic behavior,
    thermodynamics, and kinetics of these compounds were investigated to reveal the retention mechanism. The results showed that the prepared stationary phase exhibited a retention behavior of hydrophilic interaction liquid chromatography, and that
    multiple retention mechanisms including partitioning, adsorption, ion-exchange, electrostatic attraction, and coordination
    interactions contributed to solute retention. The coordination of nickel oxide electron-accepting sites and the electrondonating solutes resulted in the mixed-mode retention on stationary phase, which could be very useful for enhancing the chromatographic selectivity for the analytes. The batch-to-batch reproducibility was acceptable with the relative standard deviations of probe retention of less than 9.89%. The prepared nickel oxide deposited silica stationary phase was successfully employed for the separation of several compounds, and it showed better separation effect and different selectivity from silica column and commercial Zorbax NH2 column.

  • Co-author:

    Yingjie Guo, Xitian Peng*, Qiongwei Yu*, Yuqi Feng*

  • Indexed by:

    Journal paper

  • Discipline:

    Natural Science

  • Document Type:

    J

  • Volume:

    86

  • Page Number:

    125-134

  • Translation or Not:

    no

  • Date of Publication:

    2023-01-18

  • Included Journals:

    SCI

  • Links to published journals:

    https://doi.org/10.1007/s10337-023-04235-6

Attachments:

1.guoyj.pdf

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