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Chaotropic Effect-Induced Sol–Gel Transition and Radical Stabilization for Bacterially Sensitive Near-Infrared Photothermal Therapy

  • Date:2024-04-08
  • Hits:

  • DOI number: 

    10.1021/acs.nanolett.4c00860

  • Journal: 

    Nano Letters

  • Place of Publication: 

    美国

  • Abstract: 

    Deep-seated bacterial infections (DBIs) are stubborn and deeply penetrate tissues. Eliminating deep-seated bacteria and promoting tissue regeneration remain great challenges. Here, a novel radical-containing hydrogel (SFT-B Gel) cross-linked by a chaotropic effect was designed for the sensing of DBIs and near-infrared photothermal therapy (NIR-II PTT). A silk fibroin solution stained with 4,4′,4″-(1,3,5-triazine-2,4,6-triyl)tris(1-methylpyridin-1-ium) (TPT3+) was employed as the backbone, which could be cross-linked by a closo-dodecaborate cluster (B12H122–) through a chaotropic effect to form the SFT-B Gel. More interestingly, the SFT-B Gel exhibited the ability to sense DBIs, which could generate a TPT2+• radical with obvious color changes in the presence of bacteria. The radical-containing SFT-B Gel (SFT-B★ Gel) possessed strong NIR-II absorption and a remarkable photothermal effect, thus demonstrating excellent NIR-II PTT antibacterial activity for the treatment of DBIs. This work provides a new approach for the construction of intelligent hydrogels with unique properties using a chaotropic effect.

  • Indexed by: 

    Journal paper

  • Document Code: 

    10.1021/acs.nanolett.4c00860

  • Translation or Not: 

    no

  • Date of Publication: 

    2024-04-08

  • Included Journals: 

    SCI

  • Links to published journals: 

    https://doi.org/10.1021/acs.nanolett.4c00860
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