Self-Adapting Biomass Hydrogel Embodied with miRNA Immunoregulation and Long-Term Bacterial Eradiation for Synergistic Chronic Wound Therapy
发布时间：2025-08-12点击次数：
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影响因子：15.8
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所属单位：第一临床学院
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发表刊物：ACS NANO
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关键字：self-adapting biomass hydrogel,chronic diabetic woundhealing,long-term antibacterial activity,M2 macrophagepolarization,immunoregulation
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摘要：Chronic wound rescue is critical for diabetic patients but is challenging to achieve with a specific and long-term strategy. The prolonged bacterial inflammation is particularly prevalent in hyperglycemia-induced wounds, usually leading to severe tissue damage. Such a trend could further suffer from an environmental suitability provided by macrophages for persisting Staphylococcus aureus (S. aureus) and even deteriorate by their mutual reinforcement. However, the strategy of both suppressing bacteria growth and immunoreprogramming the inflammatory type of macrophages to break their vicious harm to wound healing is still lacking. Here, a self-adapting biomass carboxymethyl chitosan (CMC) hydrogel comprising immunomodulatory nanoparticles is reported to achieve Gram-negative/Gram-positive bacteria elimination and anti-inflammatory cytokines induction to ameliorate the cutaneous microenvironment. Mechanistically, antibacterial peptides and CMCs synergistically result in a long-term inhibition against methicillin-resistant S. aureus (MRSA) over a period of 7 days, and miR-301a reprograms the M2 macrophage via the PTEN/PI3K gamma/mTOR signaling pathway, consequently mitigating inflammation and promoting angiogenesis for diabetic wound healing in rats. In this vein, immunoregulatory hydrogel is a promising all-biomass dressing ensuring biocompatibility, providing a perspective to regenerate cutaneous damaged tissue, and repairing chronic wounds on skin.
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合写作者：Wu, Jun;Wu, Yang;Tang, Heng;Li, Wei;Zhao, Ze;Shi, Xiaowen;Jiang, Hong;Yu, Lilei;Deng, Hongbing
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论文类型：期刊论文
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论文编号：WOS_a8c71266-3c81-4b39-8dc9-467b71117b9a
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卷号：18
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期号：28
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ISSN号：1936-0851
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是否译文：否
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发表时间：2025-06-14
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赵泽
职务：副教授
主要任职：
个人信息
- 教师英文名称：Zhao Ze
- 教师拼音名称：Zhao Ze
- 电子邮箱：
- 入职时间：2021-12-09
- 所在单位：资源与环境科学学院
- 职务：副教授
- 学历：博士研究生毕业
- 办公地点：信息学部附三教学楼120办公室
- 性别：男
- 在职信息：在职
- 学科：材料加工工程
环境科学与工程其他专业
环境科学
学术荣誉：
- 2023当选：省高端人才
曾获荣誉：
- 2023湖北省“百人计划”高层次人才
- 2023武汉英才
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