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本课题组对微生物表观遗传学、氧化胁迫与进化、临床致病菌致病新机制有浓厚的兴趣。

热忱欢迎有科研追求、强烈上进心的同学加入课题组！

科研项目：

1. 国家自然科学基金面上项目，2026-2029

2. 国家自然科学基金青年项目，2024-2026

3. 国家重点研发计划子课题，2025-2029

4. 湖北省青年拔尖人才计划，2026-2029

5. 湖北省科技部自然科学青年基金，2023-2025

教学课程：

1. 公共卫生学院研究生课程《生物医学研究方法与前沿技术》，课程负责人

2. 公共卫生学院本科生课程《专业英语》，课程负责人

3. 第二临床学院全英文课程《科学交流与实践》，课程负责人

4. 第二临床学院 《留学生论文写作指导》

5. 第二临床学院《留学生MBBS诊断学》

6. 武汉大学通识课《疫苗与健康》

本科生项目：

带队大学生创新比赛项目5项在研（第一指导老师），其中国家级1项，省级1项。大力支持本科生参与科研、发表学术论文。

     近五年文章发表：

1.     Mycobacterium tuberculosis MEM39 (Rv1977) hijacks host aldolase A (ALDOA) to subvert immunometabolism to facilitate bacterial intracellular survival, Zhou, Yuanyuan; Liu, Min; Qu, Zilu; Li, Zhongkun; Xie, Yan; Zhou, Yidan*; Zhang, Xiao-Lian*; Cellular & Molecular Immunology, 2026

2.     Targeted Removal of HCV E2 N2 N-Glycan Is Associated with Improved Immune Responses in Mice, Min, Yuan-Qin; Ren, Yu-Shan; Zhang, Wen-Wen; Zhou, Yidan*; Liu, Min*; biomolecules, 2026

3.     Pyrvinium pamoate inhibits the survival of intracellular Mycobacterium tuberculosis through suppression of macrophage ferroptosis, Guan, Qing; Zhou, Yuanyuan; Han, Jian-Li; Guo, Fangyi; Li, Zhongkun; Zhou, Yidan*; Zhang, Xiao-Lian*; Bioorganic Chemistry, 2026

4.     pgRNA-m6A levels associate with HBV replication and liver function, Yang, Chaoqi; Qin, Shanshan; Gao, Rui-Huan; Li, Anling; Song, Shihui; Zhou, Yidan*; Liu, Song-Mei*; Epigenetics, 2026

5.     A stretchable, transparent, photothermally stimulated laser-induced graphene patch for noninvasive skin tumor treatment, Xu, Xiaoyu; Cheng, Le; Li, Baoping; Wang, Xinyu; Chen, Siyu; Li, Zihao; Zhou, Li; Liu, Tengyue; Zhou, Yidan; Li, Zhiqiang; Li, Xin*; Chen, Shi*; Gu, Meijia*; Ye, Ruquan*; ACS nano, 2026

6.     PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses, Shi, Mengling; Wang, Cong; Chen, Zhen; Zhou, Yidan; Yue, Liang; Liu, Yu; Guo, Tiannan; Shang, Jun; Xu, Haotian; Zhang, Yu; Luo, Mengcheng*; Lei, Caoqi*, Nature communications, 2025

7.     PCSK9 potentiates innate immune response to RNA viruses by preventing AIP4-mediated polyubiquitination and degradation of VISA/MAVS, Fang, Han; Shi, Mengling; Wang, Cong; Zhang, Saiting; Kong, Na; Ji, Mengyao; Wang, Yan; Zhou, Yidan; Zhu, Qiyun; Zhang, Yu;Du, Shishen; Xu, Shuai*; Lei, Caoqi*; Proceedings of the National Academy of Sciences, 2025

8.     Combatting persister cells: The daunting task in post-antibiotics era, Zhou, Yidan; Liao, Hebin; Pei, Linsen; Pu, Yingying*; Cell Insight, 2023

9.     Serum Lipoprotein (a) and High-Density Lipoprotein Cholesterol Associate with Diabetic Nephropathy: Evidence from Machine Learning Perspectives; Gao, Rui-Huan; Liu, Boyang; Yang, Ying; Ran, Ruoxi; Zhou, Yidan*; Liu, Song-Mei*; Diabetes, Metabolic Syndrome and Obesity, 2023

10.  Escherichia coli Uses a Dedicated Importer and Desulfidase To Ferment Cysteine, Zhou, Yidan; Imlay, James A; mBio, 2022

11.  How Escherichia coli uses environmental cysteine, University of Illinois at Urbana-Champaign, Zhou, Yidan, 2021

12.  PE_PGRS: Vital proteins in promoting mycobacterial survival and modulating host immunity and metabolism, Xie, Yan; Zhou, Yidan*; Liu, Sheng; Zhang, Xiao‐Lian*; Cellular Microbiology, 2021

13.  Mycobacterial EST12 activates a RACK1–NLRP3–gasdermin D pyroptosis–IL-1β immune pathway, Qu, Zilu; Zhou, Jin; Zhou, Yidan; Xie, Yan; Jiang, Yanjing; Wu, Jian; Luo, Zuoqin; Liu, Guanghui; Yin, Lei; Zhang, Xiao-Lian*; Science Advances, 2020

14.  During oxidative stress the Clp proteins of Escherichia coli ensure that iron pools remain sufficient to reactivate oxidized metalloenzymes, Sen, Ananya; Zhou, Yidan; Imlay, James A; Journal of Bacteriology, 2020

15.  Escherichia coli K-12 Lacks a High-Affinity Assimilatory Cysteine Importer, Zhou, Yidan; Imlay, James A; mBio, 2020