Personal Information

  • Doctoral Supervisor
  • Master Tutor
  • (Professor)
  • Gender:

    Male
  • Contact Information:

    武汉大学化学与分子科学学院
  • Degree:

    博士
  • Discipline:

    Analytical Chemistry
  • Status:

    Employed
  • School/Department:

    化学与分子科学学院
  • Education Level:

    研究生毕业
  • Alma Mater:

    武汉大学
  • Degree:

    博士
  • Status:

    Employed
  • School/Department:

    化学与分子科学学院
  • Date of Employment:

    1995-07-01
  • Contact Information:

    武汉大学化学与分子科学学院
  • E-Mail:

Profile

教育与研究经历

 

1987.7   本科,华中师范大学,分析化学

1990.9—1995.7   硕博连读,武汉大学,分析化学

1995.7—1996.8   武汉大学讲师

1996.9—1999.8   武汉大学副教授

1999.9—至今    武汉大学教授  作为洪堡学者,曾分别在德国Halle大学、Bielefeld大学和Dortmund大学访问研究,作为Postdoctoral Research Fellow 曾在香港理工大学访问研究

教学情况

主要从事分子光谱分析及纳米传感器方法与技术研究,已发表研究论文200余篇,申请(授权)发明专利17项,其中1项为美国专利。讲授本科生《仪器分析》、《仪器分析实验》及研究生《现代分子光谱分析》、《稀土元素分析》等课程。

承担项目与课题

主持973课题:传染性疾病诊断微流控新方法及其应用研究,2007.7-2011.12

主持国家自然科学基金项目:基于量子点的活细胞多靶点同时监测新方法,2013.1-2016.12

主持国家自然科学基金项目:基于单个量子点的多功能纳米生物传感器研究,2011.1-2013.12

主持国家自然科学基金项目:基于量子点的植物激素检测及激素受体确认,2008.1-2010.12

参与国家自然科学基金创新研究群体:新型生物医学探针技术基础及应用,2006.1-2011.12

参与国家重大科学研究计划(S-973):量子点标记病毒侵染过程及宿主应答,2010.12-2014.8

参与国家重大科学研究计划(S-973):病毒与细胞作用的实时检测及可视化, 2006.12-2010.8

学术兼职

湖北省仪器仪表学会常务理事,《化学传感器》和《分析科学学报》编委

代表性成果

1.Xia Xiang, Lu Chen, Cuiling Zhang, Ming Luo, Xinghu Ji and Zhike He,A fluorescence-based colorimetric droplet platform for biosensor application to the detection of a-fetoprotein,Analyst, 2012, 137, 5586
2.Guohua Zhou, Yizhen Liu, Ming Luo, Qinfeng Xu, Xinghu Ji, and Zhike He, Peptide-Capped Gold Nanoparticle for Colorimetric Immunoassay of Conjugated Abscisic Acid, ACS Appl. Mater. Interfaces 2012, 4, 5010−5015
3.Xia Xiang, Ming Luo, Liyang Shi, Xinghu Ji, Zhike He,Droplet-based microscale colorimetric biosensor for multiplexed DNA analysis via a graphene nanoprobe, Analytica Chimica Acta, 2012,  751, 155– 160
4.Peng Zhou, Qingying Luo, Yi Lin, Lu Chen, Sha Li, Guohua Zhou, Xinghu Ji, and Zhike He,Immunoassays with Protein Misfolding Cycle Amplification: A Platform for Ultrasensitive Detection of Antigen,Anal. Chem. 2012, 84(17), 7343−7349
5.Cuiling Zhang, Ding Gao, Guohua Zhou, Lu Chen, Xian-an Zhang, Zongqiang Cui and Zhike He,Label-Free Homogeneous Immunosensor Based on FRET for the Detection of Virus Antibody in Serum,Chem. Asian J. 2012, 7(8),1764-1767
6.Dong-Shan Xiang, Guo-Hua Zhou Ming Luo, Xing-Hu Ji and Zhi-Ke He,Dual color fluorescence quantitative detection of specific single-stranded DNA with molecular beacons and nucleic acid dye SYBR Green I,Analyst, 2012, 137, 3787–3793
7.Cuiling Zhang, Jing Xu, Shiming Zhang, Xinghu Ji, and Zhike He,One-Pot Synthesized DNA–CdTe Quantum Dots Applied in Biosensor for the Detection of Sequence-Specific Oligonucleotides,Chem. Eur. J. 2012, 18(27), 8296 –8300
8.Ming Luo, Xia Xiang, Dongshan Xiang, Si Yang,Xinghu Ji and Zhike He,A universal platform for amplified multiplexed DNA detection based on exonuclease III-coded magnetic microparticle probes,Chem. Commun., 2012, 48(59), 7416–7418
9.Xi Chen, Jin Chen, Fubin Wang, Xia Xiang, Ming Luo, Xinghu Ji, Zhike He,Determination of glucose and uric acid with bienzyme colorimetry on microfluidic paper-based analysis devices,Biosensors and Bioelectronics, Biosensors and Bioelectronics, 2012, 35, 363–368,
10.Lu Chen, Xiaowei Zhang, Guohua Zhou, Xia Xiang, Xinghu Ji, Zhenhua Zheng, Zhike He, Hanzhong Wang, Simultaneous Determination of Human Enterovirus 71 and Coxsackievirus B3 by Dual-Color Quantum Dots and Homogeneous Immunoassay, Anal. Chem. 2012, 84, 3200−3207
11.Xia Xiang, Lu Chen, Qinggeng Zhuang, Xinghu Ji, Zhike He,Real-time luminescence-based colorimetric determination of double-strand DNA in droplet on demand,Biosensors and Bioelectronics, 2012, 32(1), 43-49
12.Ming Luo, Xi Chen, Guohua Zhou, Xia Xiang, Lu Chen, Xinghu Ji and Zhike He,Chemiluminescence biosensors for DNA detection using graphene oxide and a horseradish peroxidase-mimicking DNAzyme,Chem. Commun., 2012, 48, 1126-1128
13.Peng Zhou, Zhenhua Zheng, Wen Lu, Fuxian Zhang, Zhenfeng Zhang, Daiwen Pang, Bin Hu,Zhike He, and Hanzhong Wang, Multicolor Labeling of Living-Virus Particles in Live Cells, Angew. Chem. Int. Ed., 2012, 51 (3), 670-674
14.Lu Chen, Xiaowei Zhang, Cuiling Zhang, Guohua Zhou, Wanpo Zhang, Dongshan Xiang, Zhike He and Hanzhong Wang,Dual-Color Fluorescence and Homogeneous Immunoassay for the Determination of Human Enterovirus 71,Anal. Chem., 2011, 83 (19), 7316–7322
15.Dan Zhao,a,b Yang Fang,a Haoyuan Wanga and Zhike He,Synthesis and Characterization of High-Quality Water-Soluble CdTe: Zn2+Quantum Dots Capped by N-acetyl-L-cysteine Via Hydrothermal Method,Journal of Materials Chemistry. 2011, 21, 13365-13370
16.Dong-shan Xiang, Guo-ping Zeng, Zhi-ke He,Magnetic microparticle-based multiplexed DNA detection with biobarcoded quantum dot probes,Biosensors and Bioelectronics, 2011, 26 , 4405–4410
 

获奖与荣誉

2009年获第六届高等教育国家级教学成果二等奖

2009年获湖北省优秀教学成果一等奖

2000年获湖北省自然科学二等奖

Educational Experience

  • [1]1982.9-1985.6

    荆州师范专科学校

    获化学系当年唯一一个保送华中师范大学插班的机会

  • [2]1985.9-1987.6

    华中师范大学  | 学士 | 大学普通班毕业

    插班生

  • [3]1990.9-1995.6

    武汉大学  | 分析化学  | 博士 | 研究生毕业

Social Affiliations

  • [1]2018.1-2021.12

    《Chinese Chemical Letters》 通讯编委

Research Group

[1]Name of Research Group:He' Group

Description of Research Group:

何治柯教授和吉邢虎副教授,主要从事量子点等纳米材料制备及生物医学分析应用、微流控芯片技术及分析应用研究

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