1.糖尿病创面修复

[1]The ROS-responsive FA@Ni@HA hydrogel promotes infected wound healing in DIO mice through endogenous antimicrobial peptides and macrophage recruitment.Chemical Engineering Journal.Volume 500, 15 November 2024, 157300

[2]MMP-9 responsive hydrogel promotes diabetic wound healing by suppressing ferroptosis of endothelial cells.Bioactive Materials.2025,43：240-254

[3]Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization.Bioactive Materials.2024,33：157-173 ESI全球1%高被引与0.1%热点论文，100篇湖北省优秀科技论文

[4]Glucose-responsive, antioxidative HA-PBA-FA/EN106 hydrogel enhanced diabetic wound healing through modultion of FEM1b-FNIP1 axis and promoting angiogenesis.Bioactive Materials.2023,30：29-45 封面论文，100篇湖北省优秀科技论文

2.微针技术在皮肤治疗领域的应用

[1]Double-Layered Microneedle Patch Integrated with Multifunctional Nanoparticles and Live Bacteria for Long-Term Treatment of Atopic Dermatitis.Small.2024,21(3)：202409121 (微针贴片治疗特应性皮炎)

[2]Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis.International Journal of Pharmaceutics.2025,669:125073（聚合物微针递送的自组装透明质酸纳米颗粒用于银屑病的靶向长效治疗）

3.猴痘基础及临床研究

[1]Clinical, Epidemiological, Virological Characteristics and Outcomes of 286 Patients Infected With Monkeypox Virus in China.Allergy.2025,3:16540

（中国 286 例猴痘病毒感染患者的临床、流行病学、病毒学特征及预后）

[2] HIV-猴痘等共感染免疫特征及关键防控策略.中华传染病杂志.（311365-20250421-00118） 

4.中药功效的科学表征及质量评价

[1]Metabolomic and lipidomic profiling of traditional Chinese medicine Testudinis Carapax et Plastrumand its substitutes.Frontiers in Pharmacology.2025,16: 1549834

（十大楚药“龟甲”首次全面的成分分析及混伪品比较）

[2]冬虫夏草繁育品保健功能的多组学研究．中国医药工业杂志.2025, 56(2): 205-216

[3]Comparative metabolic profiling of wild Cordyceps species and their substituents by liquid chromatography-tandem mass spectrometry.Frontiers in Pharmacology.2022,13：1036589（各品类冬虫夏草代谢物特征标志物筛选及代谢物全成分解析）

[4]Lipidomic profiling of wild cordyceps and its substituents by liquid chromatography-electrospray ionization-tandem mass spectrometry.LWT - Food Science and Technology.2022, 163: 113497（各品类冬虫夏草脂质特征标志物筛选及全脂质成分解析）

[5]Fast quantification of free amino acids in food by microfluidic voltage-assisted liquid desorption electrospray ionization-tandem mass spectrometry.Analytical and Bioanalytical Chemistry.2020,412(8):1947-1954（食品及冬虫夏草中游离氨基酸快速定量检测新方法—微流体电压辅助液体解吸电喷雾电离串联质谱法）

[6]一种高效液相色谱法测定虫草中虫草素含量的方法.第一发明人.ZL201910699621.6

[7] Multi-omics analysis reveals the healthy functions of Oviductus Ranae.Pharmacological Research - Modern Chinese Medicine.2024, 10: 100369 

 (多组学分析揭示哈蟆油<雪蛤>的保健功效)

[8]基于宏基因组技术研究哈蟆油对大鼠肠道菌群的影响.药物流行病学杂志.2023,32(09):1008-1016

[9]基于宏基因组学技术研究生态繁育冬虫夏草对大鼠肠道菌群的影响.中国药师.2022,25(12):2137-2143

[10]基于网络药理学和分子对接研究冬虫夏草治疗糖尿病肾病的作用机制.中国药师.2021,24(06):1057-1063 

5.基于质谱在线多组学技术的药物安全性评价微流控器官芯片系统 

[1]器官芯片技术在药物毒理学领域的研究现状及应用前景.世界临床药物.2023,44(01):83-89

[2]Fast quantification of free amino acids in food by microfluidic voltage-assisted liquid desorption electrospray ionization-tandem mass spectrometry.Analytical and Bioanalytical Chemistry.2020,412(8):1947-1954

[3]Direct Analysis of Biofluids by Mass Spectrometry with Microfluidic Voltage-Assisted Liquid Desorption Electrospray Ionization.Analytical Chemistry.2017,89(22):12014-12022

[4]A microchip electrophoresis-mass spectrometric platform with double cell lysis nano-electrodes for automated single cell analysis.Journal of Chromatography A.2016,1451156-163

[5]Microfluidic Platform with In-Chip Electrophoresis Coupled to Mass Spectrometry for Monitoring Neurochemical Release from Nerve Cells.Analytical Chemistry.2016,88(10):5338-44

[6]D-serine uptake and release in PC-12 cells measured by chiral microchip electrophoresis-mass spectrometry.ACS Chemical Neuroscience.2015,6(4):582-587

器官芯片系统组件—中国实用新型专利授权—质谱前生物样本自动化处理设备

[1]脂溶性物质自动化处理设备.第一发明人.ZL202320296097.X

[2]蛋白质提取多肽水解自动化处理设备.第一发明人.ZL202320296412.9

[3]极性代谢物自动化处理设备.第一发明人.ZL202320296211.9

器官芯片系统—中国发明专利授权

[1]器官微流控芯片及药物安全性评价系统.第一发明人.ZL202310155973.1

[2]一种人体器官芯片微流控系统和实现方法.第一发明人.ZL202210809791.7

[3]一种人体器官芯片微流控系统和实现方法.第一发明人.ZL202210810808.0

奖励荣誉

[1]2024年第九届创客中国生物制造中小企业创新创业大赛一等奖.（2024年创客中国全国500强）

[2]彩云汇创新创业大赛暨2024年云南省创新创业大赛一等奖.

• [1].  β-catenin disruption decreases macrophage exosomal α-SNAP and impedes Treg differentiation in acute liver injury.  JCI insight. 
• [2].  MMP-9 responsive hydrogel promotes diabetic wound healing by suppressing ferroptosis of endothelial cells.  Bioactive Materials Volume 43 , January 2025, Pages 240-254. 
• [3].  Multi-omics analysis reveals the healthy functions of Oviductus Ranae.  Pharmacological Research - Modern Chinese Medicine.  2024. 
• [4].  Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization.  Bioactive Materials.  2023. 
• [5].  Glucose-responsive, antioxidative HA-PBA-FA/EN106 hydrogel enhanced diabetic wound healing through modulation of FEM1b-FNIP1 axis and promoting angiogenesis.  Bioactive Materials.  2023.  入选湖北科协100篇湖北优秀科技论文（2021-2023）.

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• [1].  一种阿昔替尼药物制剂及其制备方法—中国发明专利—第一发明人.  武汉大学中南医院.  2023-06-14.  ZL202210786731.8.
• [2].  一种炎琥宁无菌原料药的制备方法—中国发明专利—第一发明人.  武汉大学.  2023-04-07.  ZL201910800928.0.
• [3].  一种盐酸二甲双胍化合物及盐酸二甲双胍片组合物—中国发明专利—第一发明人. 
• [4].  碳酸氢钠注射液包装用碳酸氢钠缓释片—中国发明专利—第一发明人. 
• [5].  碳酸氢钠林格注射液及其制备方法—中国发明专利—第一发明人. 

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• [1].  《药物剂型与合理使用》主编 . 人民卫生出版社

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