李武，教授，博士生导师，入选国家级青年人才项目（2022年)。2015年在武汉大学获得博士学位，导师雷爱文教授。2016-2021年在德国莱布尼茨催化研究所从事博士后研究，合作导师Matthias Beller教授。2022年2月入职武汉大学化学与分子科学学院。聚焦催化氘标记化学,以通讯/共同通讯作者身份发表论文19篇，其中包括：Nature （1篇）、Nat. Catal.（1篇）、Nat. Synth.（2篇）、Chem. Soc. Rev.（1篇）、J. Am. Chem. Soc. （3篇）、 Angew. Chem. Int. Ed.（1篇）、Nat. Commun.（1篇）等。曾获武汉英才“优秀青年人才”、湖北省优秀博士学位论文、武汉大学“十大珞珈风云学子” 、“十大学术之星”等奖励和荣誉。主要从事：催化同位素标记化学；电化学和电催化同位素标记；纳米催化剂的设计、创制及其催化同位素标记应用。在本科生培养方面，重视本科生培养, 2025年，指导的本科生获得创新实验设计大赛国家级二等奖；过去三年指导了14位本科生毕业设计，其中1人获得武汉大学优秀本科毕业论文；近两年指导5项大创项目和两项创新实验设计。欢迎对科研感兴趣的本科生进课题组开展业余科研。欢迎优秀学子报考博士或硕士研究生(包括推荐免试研究生和直博生)，同时招聘博士后/研究助理(长期有效)，优秀者可以申请武汉大学“卓越博士后”计划，并欢迎本科生来课题组交流学习。请有意申请者将个人简历、科研工作总结/代表性论文发至邮箱：wu.li@whu.edu.cn。进一步了解研究方向可参考B站视频：https://www.bilibili.com/video/BV1dj411U7Tz/?spm_id_from=333.337.search-card.all.click&vd_source=81b65167cd815b172f62cb029a1f29cb
近5年在氘标记化学方面代表性成果：
1. Bu, F.#, Deng, Y.#, Xu, J., Yang, D., Li, Y., Li, W.* and Lei, A.*, Electrocatalytic reductive deuteration of arenes and heteroarenes. Nature 2024, 634, 592–599.
2. He, M#, Deng, X.#, Yao. F#, Wang. Y, Gao, Y, Wang, P., Wan, Q., Chen, K., Wang, L., Yi, H., Zhang, H.*, Li, W.* and and Lei, A.*, Boron Cluster as Efficient Shipper for Electrocatalytic Radical H/D Exchange, Nat. Catal. 2025, 8, 784–793.
3. Qiu, F., Yang, L., Wang, Y., Gao, Y., Chen, Y., Lei, A.* and Li, W.*, Nickel-Catalyzed Deuteration of Benzylic C(sp3)–H Bonds using D2O, Nat. Synth. 2025, 1141–1150.
4. Bu, F., Qiu, F., Gao, Y., Deng, Y., Lei, A., and Li, W.*, Heterogeneous catalytic deuteration using D2O and advances in the application of deuterium labelling. Chem. Soc. Rev. 2026, 55, 3645-3686.
5. Bu, F.#, Deng, Y.#, Lu, L.#, Li. Y., Song, W., Yang, Z., Luo, X., Dong, X., Yi, R., Wang, S., Lei, A.*, and Li, W.*, Electrocatalytic Alkene Hydrogenation/Deuteration, J. Am. Chem. Soc. 2025, 147, 5785−5795.
6. Bu, F.#, Deng, Y.#, Shi, P., Huang, R., Tan, J., Li, H., Chen, Y., Lei, A., and Li, W.*, Thiol-Regulated Rhodium Nanocatalyst for Electrochemical Reductive Perdeuteration of Alkenes J. Am. Chem. Soc. 2026, 148, 7322−7332.
7. Hu, J., Hu, J., Wang, Y., Zeng, C. Zhang, H. Wei, Z.*, Li, W.*, Yi, H.* and Lei, A.*, Parallel paired electrolysis of industrial exhaust SO2 and diols for value-added sulfite esters synthesis, Nat. Synth. 2026, doi.org/10.1038/s44160-025-00968-4.
8. Li, Y.#, Peng, Y.#, Dong, W.#, Jiang, X., Lu, L., Yang, D., Hsu, L-C., Li, W.*, Su, B-L.* and Lei, A.*, May 2024, Multiscale Anion-Hybrid in Atomic Ni Sites for High-Rate Water Electrolysis: Insights into the Charge Accumulation Mechanism, J. Am. Chem. Soc. 2024, 146, 14194–14202.
9. Li, H.#, Li, Y.#, Chen, J., Lu, L., Wang, P., Hu, J., Ma, R., Gao, Y., Yi, H.*, Li, W.* and Lei, A.*, Scalable and Selective Electrochemical Hydrogenation of Polycyclic Arenes, Angew. Chem. Int. Ed. 2024, 63, e202407392.
10. Li, Y., Lu, L., Jiang, X., Yang, D, Chen, J-L., Chowdhury, A. D., Li, W.*, Pei, X.*, and Lei, A.*, Dynamic Boron-doping Switched Chitin-based Single-site Pt Catalyst for Chemo-selective Hydrogenation, Nat. Commun. 2025, 16, 2296.
11. Wang, X.#, Li, Y.#, Wang, M., Gao, Y., Ma, Z., Lei, A.* and Li, W.*, Nickel nanoparticles catalyzed hydrogenation and deuteration for a general amine synthesis, Chin. J. Catal. 2025, 72, 392−401.
12. Qiu, F. #, Chen, Y.#, Liao, P., Gao, Y., Guo, M.*, Zhang, H.*, Lei, A.* and Li, W.*, Electrochemical selective deuterium labelling of N-heteroarenes, Green Synth. Catal. 2025, 6, 439-443.
13. Li, H., Shabbir, M., Li, W.* and Lei, A.*, Recent Advances in Deuteration Reactions, Chin. J. Chem. 2024, 42, 1145–1156.
14. Qiu, F., Yang, L., Gao, Y., Yang, J., Lei, A.* and Li, W.*, Selective and Scalable Deuteration of Heteroarenes Using Nickel-Based Nanoparticles, Chin. J. Chem. 2024, 42, 2993–2998.
15. Yang, L.#, Qiu, F.#, Chen, Y., Gao, Y., Wang, T.*, Lei, A.* and Li, W.*, Copper-Catalyzed Deuteration of (Hetero)Aryl Halides, Green Synth. Catal. 2024, https://doi.org/10.1016/j.gresc.2024.12.004.
16. Wang, Y.#, Qiu, F.#, Yao F., Zeng, L., Lei, A.* and Li, W.*, Ru-based nanoparticle catalyzed direct H/D exchange of silanes, Chem. Commun., 2025, 61, 6607–6610. (2025 Emerging Investigators)
17. Gao, Y.#, Li, Y.#, Su, Y., Wang, Y., Li, H., Wang, X., Li, P., Hu, J., Yi, H.*, Li, W.* and Lei, A.*, Perdeuteration of (Hetero)arenes in Flow Enabled by Defective Porous Carbon, Adv. Synth. Catal. 2025, 367, e70037.
18. Yao, F., Gao, Y., Wang, Y., Zeng, L., Lei, A. and Li, W.*, Electrochemical Deoxyarylation of Aromatic Aldehydes and Ketones, Org. Lett. 2025, 27, 4124−4128.
19. Li, W., Rabeah, J., Bourriquen, F., Yang, D., Kreyenschulte, C., Rockstroh, N., Lund, H., Bartling, S., Surkus, A-E., Junge, K., Brückner, A.*, Lei, A.*, and Beller, M.*, Scalable and selective deuteration of (hetero)arenes, Nature Chem., 2022, 14, 334–341 (Highlighted in “Synfacts”).
主要研究方向：催化氘标记化学；电催化；纳米催化；同位素标记
同位素氘标记已在药物化学、诊断成像、化学科学及材料科学等多个领域展现出广泛的应用前景。当前氘标记化学所面临的核心挑战与瓶颈在于氘物种的反应活性难以精准控制，这一局限性制约了反应的普适性、选择性及其规模化生产潜力。我们聚焦催化氘标记化学，主要取得了如下成果：通过电催化、纳米催化和自由基氘代，实现了多种含氘化学品的精准制备。以通讯作者/共同通讯作者身份在 Nature、Nat. Catal.、Nat. Synth.、Chem. Soc. Rev.、JACS 等期刊发表论文19篇。
