suwei
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- Supervisor of Doctorate Candidates
- Supervisor of Master's Candidates
- Name (Pinyin):suwei
- E-Mail:
- School/Department:泰康医学院(基础医学院)
- Education Level:With Certificate of Graduation for Doctorate Study
- Business Address:中国 湖北省 武汉市 武昌区 东湖路115号 武汉大学医学部9号楼 1104-1室
- Contact Information:suwei458@gmail.com/suwei@whu.edu.cn
- Academic Titles:教授、博导，国家级青年人才，泰康生命医学中心PI
- Alma Mater:美国田纳西健康医学中心/圣裘德儿童医院
- Teacher College:School of Basic Medical Science
- Discipline:Immunology
Other Contact Information
- PostalAddress：
- Telephone：
- Email：
- Paper Publications
CXCR6 orchestrates brain CD8+ T cell residency and limits murine Alzheimer’s disease pathology. Nature Immunology
Release time:2025-10-10 Hits:
- Journal:Nature Immunology
- Abstract:Neurodegenerative diseases, including Alzheimer’s disease (AD), are characterized by innate immune-mediated inflammation, but functional and mechanistic effects of the adaptive immune system remain unclear. Here we identify brain-resident CD8+ T cells that coexpress CXCR6 and PD-1 and are in proximity to plaque-associated microglia in human and mouse AD brains. We also establish that CD8+ T cells restrict AD pathologies, including β-amyloid deposition and cognitive decline. Ligand–receptor interaction analysis identifies CXCL16–CXCR6 intercellular communication between microglia and CD8+ T cells. Further, Cxcr6 deficiency impairs accumulation, tissue residency programming and clonal expansion of brain PD-1+CD8+ T cells. Ablation of Cxcr6 or CD8+ T cells ultimately increases proinflammatory cytokine production from microglia, with CXCR6 orchestrating brain CD8+ T cell–microglia colocalization. Collectively, our study reveals protective roles for brain CD8+ T cells and CXCR6 in mouse AD pathogenesis and highlights that microenvironment-specific, intercellular communication orchestrates tissue homeostasis and protection from neuroinflammation.
- Indexed by:Journal paper
- Translation or Not:no
- Date of Publication:2023-09-07
- Attachments: