suwei
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- Supervisor of Doctorate Candidates
- Supervisor of Master's Candidates
- Name (Pinyin):suwei
- E-Mail:
- School/Department:泰康医学院(基础医学院)
- Education Level:With Certificate of Graduation for Doctorate Study
- Business Address:中国 湖北省 武汉市 武昌区 东湖路115号 武汉大学医学部9号楼 1104-1室
- Contact Information:suwei458@gmail.com/suwei@whu.edu.cn
- Academic Titles:教授、博导，国家级青年人才，泰康生命医学中心PI
- Alma Mater:美国田纳西健康医学中心/圣裘德儿童医院
- Teacher College:School of Basic Medical Science
- Discipline:Immunology
Other Contact Information
- PostalAddress：
- Telephone：
- Email：
- Paper Publications
Protein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells
Release time:2025-10-10 Hits:
- Journal:Cell Metabolism
- Abstract:Effector regulatory T (eTreg) cells are essential for immune tolerance and depend upon T cell receptor (TCR) signals for generation. The immunometabolic signaling mechanisms that promote the differentiation and maintenance of eTreg cells remain unclear. Here, we show that isoprenoid-dependent posttranslational lipid modifications dictate eTreg cell accumulation and function by intersecting with TCR-induced intracellular signaling. We find that isoprenoids are essential for activated Treg cell suppressive activity, and Treg cell-specific deletion of the respective farnesylation- and geranylgeranylation-promoting enzymes Fntb or Pggt1b leads to the development of fatal autoimmunity, associated with reduced eTreg cell accumulation. Mechanistically, Fntb promotes eTreg cell maintenance by regulating mTORC1 activity and ICOS expression. In contrast, Pggt1b acts as a rheostat of TCR-dependent transcriptional programming and Rac-mediated signaling for establishment of eTreg cell differentiation and immune tolerance. Therefore, our results identify bidirectional metabolic signaling, specifically between immunoreceptor signaling and metabolism-mediated posttranslational lipid modifications, for the differentiation and maintenance of eTreg cells.
- Translation or Not:no
- Date of Publication:2020-12-01
- Attachments: