研究领域
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1、 肿瘤分子流行病学、前瞻性和专病队列研究建设;
2、 肿瘤遗传易感机制研究(基因表达调控;肿瘤-免疫微环境);
3、 多组学数据智能整合分析(基因组、表观调控组、转录组、蛋白组、代谢组、单细胞组);
4、 基因-环境交互作用和环境表观应对机制;
5、 肿瘤早期筛查和疾病风险预测模型构建;
论文成果
- Can Chen#, Yimin Cai#, Wenlong Hu#, Kai Tan#, Zequn Lu#, Xuanyu Zhu#, ......, Jianbo Tian* & Xiaoping Miao*.Single-cell eQTL mapping reveals cell subtype-specific genetic control and mechanism in malignant tr
- Yimin Cai#, Zequn Lu#, Can Chen#, Ying Zhu#, ...... ,Jianbo Tian* & Xiaoping Miao*..An atlas of genetic effects on cellular composition of the tumor microenvironment.Nat Immunol 2024 (IF:27.7,中科院1区)
- Cai Yimin#, Lu Zequn#, Li Bin# ...... Miao Xiaoping*, Zhang Shaokai*, Wei Yongchang*, Tian Jianbo*.Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers.Mil Med Res 2024.11(1):36 (IF:16.7, 中科院1区)
- Tian Jianbo*,Zhang Ming#, Zhang Fuwei#, Gao Kai# ...... Jin Mingjuan*, Miao Xiaoping*, Chen Kun*..Developing an optimal stratification model for colorectal cancer screening and reducing racial dispa.Genome Medicine 2024,16(1):81(IF:10.4, 中科院1区)
- Ying Pingting#, Chen Can#, Lu Zequn #, ...... ,Tian Jianbo*, Miao Xiaoping*..Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human canc.Nature communications 2023,14(1):5958(IF:16.6, 中科院1区)
专利
科研项目
科研团队
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