Research
Bi-Feng Yuan studied biochemistry and biophysics at Wuhan University in China, where he received his BSc and Ph.D. degrees in 2001 and 2006, respectively. From 2006-2007 and 2007-2010, he worked as a postdoctoral researcher in the Department of Biological Sciences at National University of Singapore and in the Department of Chemistry at University of California Riverside, respectively. He joined Wuhan University in 2011 and is currently a Professor in the School of Public Health. His research focuses on the development and application of new analytical techniques in the investigation of the occurrence, location, and biological functions of nucleic acid modifications.
1. Environmental epigenetics
Epigenetic modifications of nucleic acids play a crucial role in gene regulation and are key players in the development of various diseases, including cancer. Our research is dedicated to investigating the physiological functions of epigenetic modifications of nucleic acids by establishing sensitive and specific analytical methods such as mass spectrometry and sequencing techniques. Additionally, we explore the impact and mechanisms of environmental factors on epigenetic modifications, aiming to provide new strategies and insights for the prevention and treatment of related diseases.
2. Metabolomics
We are dedicated to developing metabolomics and exposomics research methods based on mass spectrometry technology, in conjunction with appropriate biological approaches, to identify disease biomarkers. Our research aims to comprehensively explore the vital physiological functions of metabolites in disease occurrence and progression, while also investigating the impact and mechanisms of environmental factors on life metabolism. Our goal is to provide novel strategies and insights for the prevention, diagnosis, and treatment of related diseases.
Selected publications
1. Xie, N.B., Wang, M., Chen, W., Ji, T.T., Guo, X., Gang, F.Y., Wang, Y.F., Feng, Y.Q., Liang, Y.,* Ci, W.,* and Yuan, B.F.* (2023) Whole-Genome Sequencing of 5‑Hydroxymethylcytosine at Base Resolution by Bisulfite-Free Single-Step Deamination with Engineered Cytosine Deaminase, ACS Cent Sci, 9, 2315-2325.
2. Ma, C.J., Li, G., Shao, W.X., Min, Y.H., Wang, P., Ding, J.H., Xie, N.B., Wang, M., Tang, F., Feng, Y.Q., Ci, W.,* Wang, Y.,* and Yuan, B.F.* (2023) Single-Nucleotide Resolution Mapping of N6‑Methyladenine in Genomic DNA. ACS Cent Sci, 9, 1799-1809.
3. Shao, W.X., Min, Y.H., Chen, W., Xiong, J., Guo, X., Xie, N.B., Zhang, S., Yu, S.Y., Xie, C., Feng, Y.Q. and Yuan, B.F.* (2023) Single-Base Resolution Detection of N(6)-Methyladenosine in RNA by Adenosine Deamination Sequencing. Anal Chem, 95, 10588-10594.
4. Ji, T.T., Xie, N.B., Ding, J.H., Wang, M., Guo, X., Chen, Y.Y., Yu, S.Y., Feng, Y.Q. and Yuan, B.F.* (2023) Enzymatic Cleavage-Mediated Extension Stalling Enables Accurate Recognition and Quantification of Locus-Specific Uracil Modification in DNA. Anal Chem, 95, 8384-8392.
5. Wang, M., Xie, N.B., Chen, K.K., Ji, T.T., Xiong, J., Guo, X., Yu, S.Y., Tang, F., Xie, C., Feng, Y.Q. and Yuan, B.F.* (2023) Engineered APOBEC3C Sequencing Enables Bisulfite-Free and Direct Detection of DNA Methylation at a Single-Base Resolution. Anal Chem, 95, 1556-1565.
6. Ding, J.H., Chen, M.Y., Xie, N.B., Xie, C., Xiong, N., He, J.G., Wang, J., Guo, C., Feng, Y.Q. and Yuan, B.F.* (2023) Quantitative and site-specific detection of inosine modification in RNA by acrylonitrile labeling-mediated elongation stalling. Biosens Bioelectron, 219, 114821.
7. Tao, W.B., Xie, N.B., Cheng, Q.Y., Feng, Y.Q. and Yuan, B.F.* (2023) Sensitive determination of inosine RNA modification in single cell by chemical derivatization coupled with mass spectrometry analysis. Chin Chem Lett, 34, 108243.
8. Chen, Y.Y., Gui, Z., Hu, D., Chen, M.Y., He, J.G., Yu, S.Y., Feng, Y.Q., Wang, J. and Yuan, B.F.* (2023) Adolescent alcohol exposure changes RNA modifications in adult brain by mass spectrometry-based comprehensive profiling analysis. Chin Chem Lett, 34, 108522.
9. Xiong, J., Wang, P., Shao, W.X., Li, G.J., Ding, J.H., Xie, N.B., Wang, M., Cheng, Q.Y., Xie, C.H., Feng, Y.Q., Ci, W.M.* and Yuan, B.F.* (2022) Genome-wide mapping of N-4-methylcytosine at single-base resolution by APOBEC3A-mediated deamination sequencing. Chem Sci, 13, 9960-9972.
10. Xiong, J., Chen, K.K., Xie, N.B., Ji, T.T., Yu, S.Y., Tang, F., Xie, C., Feng, Y.Q. and Yuan, B.F.* (2022) Bisulfite-Free and Single-Base Resolution Detection of Epigenetic DNA Modification of 5-Methylcytosine by Methyltransferase-Directed Labeling with APOBEC3A Deamination Sequencing. Anal Chem, 94, 15489-15498.
11. You, X.J., Zhang, S., Chen, J.J., Tang, F., He, J., Wang, J., Qi, C.B., Feng, Y.Q., Yuan, B.F.* (2022) Formation and removal of 1,N6-dimethyladenosine in mammalian transfer RNA. Nucleic Acids Res. 50, 9858-9872.
12. Tang, F., Yuan, J., Yuan, B.F.* and Wang, Y.* (2022) DNA−Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol. J Am Chem Soc, 144, 454-462.
13. Chen, J.J., You, X.J., Li, L., Xie, N.B., Ding, J.H., Yuan, B.F.* and Feng, Y.Q. (2022) Single-Base Resolution Detection of Adenosine-to-Inosine RNA Editing by Endonuclease-Mediated Sequencing. Anal Chem, 94, 8740-8747..
14. Xie, N.B., Wang, M., Ji, T.T., Guo, X., Ding, J.H., Yuan, B.F.* and Feng, Y.Q. (2022) Bisulfite-free and single-nucleotide resolution sequencing of DNA epigenetic modification of 5-hydroxymethylcytosine using engineered deaminase. Chem Sci, 13, 7046–7056.
15. Feng, Y.J., You, X.J., Ding, J.H., Zhang, Y.F., Yuan, B.F.* and Feng, Y.Q. (2022) Identification of Inosine and 2'-O-Methylinosine Modifications in Yeast Messenger RNA by Liquid Chromatography-Tandem Mass Spectrometry Analysis. Anal Chem, 94, 4747-4755.
16. Chen, M.Y., Qi, C.B., Tang, X.M., Ding, J.H., Yuan, B.F.* and Feng, Y.Q. (2022) Comprehensive profiling and evaluation of the alteration of RNA modifications in thyroid carcinoma by liquid chromatography-tandem mass spectrometry. Chin Chem Lett, 33, 3772-3776.
17. Chen, M.Y., Gui, Z., Chen, K.K., Ding, J.H., He, J.G., Xiong, J., Li, J.L., Wang, J., Yuan, B.F.* and Feng, Y.Q. (2022) Adolescent alcohol exposure alters DNA and RNA modifications in peripheral blood by liquid chromatography-tandem mass spectrometry analysis. Chin Chem Lett, 33, 2086-2090.
18. Ma, C.J., Li, L., Shao, W.X., Ding, J.H., Cai, X., Lun, Z., Yuan, B.F.* and Feng, Y.Q. (2021) Enzyme-mediated bioorthogonal labeling method for genome-wide mapping of 5-hydroxymethyluracil. Chem Sci, 12, 14126-14132.
19. Feng, Y., Chen, J.J., Xie, N.B., Ding, J.H., You, X.J., Tao, W.B., Zhang, X., Yi, C., Zhou, X., Yuan, B.F.* and Feng, Y.Q. (2021) Direct decarboxylation of Ten-eleven translocation-produced 5-carboxylcytosine in mammalian genomes forms a new mechanism for active DNA demethylation. Chem Sci, 12, 11322-11329.
20. Cheng, M.Y., You, X.J., Ding, J.H., Dai, Y., Chen, M.Y., Yuan, B.F.* and Feng, Y.Q. (2021) Novel dual methylation of cytidines in RNA of mammals. Chem Sci, 12, 8149–8156.
21. Dai, Y., Yuan, B.F.* and Feng, Y.Q. (2021) Quantification and mapping of DNA modifications. RSC Chem Biol, 2, 1096–1114.
22. Dai, Y., Qi, C.B., Feng, Y., Cheng, Q.Y., Liu, F.L., Cheng, M.Y., Yuan, B.F.* and Feng, Y.Q. (2021) Sensitive and Simultaneous Determination of Uridine Thiolation and Hydroxylation Modifications in Eukaryotic RNA by Derivatization Coupled with Mass Spectrometry Analysis. Anal Chem. 93, 6938-6946.
23. Liu, F.L., Ye, T.T., Ding, J.H., Yin, X.M., Yang, X.K., Huang, W.H., Yuan, B.F.* and Feng, Y.Q. (2021) Chemical Tagging Assisted Mass Spectrometry Analysis Enables Sensitive Determination of Phosphorylated Compounds in a Single Cell. Anal Chem, 93, 6848-6856.
24. Wang, Q., Ding, J.H., Xiong, J., Feng, Y., Yuan, B.F.* and Feng, Y.Q. (2021) Site-specific quantification of 5-carboxylcytosine in DNA by chemical conversion coupled with ligation-based PCR. Chin Chem Lett, 32, 3426-3430.
25. Jeschke, J., Collignon, E., Al Wardi, C., Krayem, M., … Yuan, B.F., Willard-Gallo, K., Sotiriou, C., Marine, J.C. and Fuks, F.* (2021) Downregulation of the FTO m(6)A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors. Nat Cancer, 2, 611-628.
26. Feng, Y., Xie, N.B., Tao, W.B., Ding, J.H., You, X.J., Ma, C.J., Zhang, X., Yi, C., Zhou, X., Yuan, B.F.* and Feng, Y.Q. (2020) Transformation of 5-Carboxylcytosine to Cytosine Through C–C Bond Cleavage in Human Cells Constitutes a Novel Pathway for DNA Demethylation. CCS Chem, 2, 994-1008.
27. Cheng, Q.Y., Xiong, J., Ma, C.J., Dai, Y., Ding, J.H., Liu, F.L., Yuan, B.F.* and Feng, Y. Q. (2020) Chemical tagging for sensitive determination of uridine modifications in RNA, Chem Sci, 11, 1878-1891.
28. Ding, J.H., Ma, C.J., Chen, M.Y., Chen, B., Yuan, B.F.* and Feng, Y.Q. (2020) Quantification and single-base resolution analysis of N1-methyladenosine in mRNA by ligation-assisted differentiation. Anal Chem, 92, 2612-2619.
29. Liu, F.L, Qi, C.B., Cheng, Q.Y., Ding, J.H., Yuan, B.F.* and Feng, Y.Q. (2020) Diazo reagent labeling with mass spectrometry analysis for sensitive determination of ribonucleotides in living organisms. Anal Chem, 92, 2301-2309.
30. Lan, J., Rajan, N., Bizet, M., Penning, A.,… Yuan, B.F. and Fuks, F.* (2020) Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation. Nat Commun, 11, 4956.
31. You, X.J., Liu, T., Ma, C.J., Qi, C.B., Tong, Y., Zhao, X., Yuan, B.F.* and Feng, Y.Q. (2019) Determination of RNA hydroxylmethylation in mammals by mass spectrometry analysis. Anal Chem, 91, 10477-10483.
32. Tang, F., Liu, S., Li, Q.Y., Yuan, J., Li, L., Wang, Y., Yuan, B.F.* and Feng, Y.Q. (2019) Location analysis of 8-oxo-7,8-dihydroguanine in DNA by polymerase-mediated differential coding. Chem Sci, 10, 4272–4281.
33. Xiong, J., Ye, T.T., Ma, C.J., Cheng, Q.Y., Yuan, B.F.* and Feng, Y.Q. (2019) N6-Hydroxymethyladenine: a hydroxylation derivative of N6-methyladenine in genomic DNA of mammals. Nucleic Acids Res, 47, 1268-1277.
34. Chen, B., Yuan, B.F.* and Feng, Y.Q. (2019) Analytical Methods for Deciphering RNA Modifications. Anal Chem, 91, 743-756.
35. Xu, J., Zhang, Q.F., Zheng, J., Yuan, B.F.* and Feng, Y.Q.* (2019) Mass spectrometry-based fecal metabolome analysis. TrAC-Trend Anal Chem, 112, 161-174.
36. Ma, C.J., Ding, J.H., Ye, T.T., Yuan, B.F.* and Feng, Y.Q. (2019) AlkB Homologue 1 Demethylates N(3)-Methylcytidine in mRNA of Mammals. ACS Chem Biol, 14, 1418-1425.
37. Qi, C.B., Jiang, H.P., Xiong, J., Yuan, B.F.*, and Feng, Y.Q. (2019) On-line trapping/capillary hydrophilic-interaction liquid chromatography/mass spectrometry for sensitive determination of RNA modifications from human blood. Chin Chem Lett, 30, 553-557.
38. Qi, C.B., Ding, J.H., Yuan, B.F.*, and Feng, Y.Q. (2019) Analytical methods for locating modifications in nucleic acids. Chin Chem Lett, 30, 1618-1626.
39. Lan, M.D., Yuan, B.F.*, and Feng, Y.Q. (2019) Deciphering nucleic acid modifications by chemical derivatization-mass spectrometry analysis. Chin Chem Lett, 30, 1-6.
40. Li, Q.Y., Xie, N.B., Xiong, J., Yuan, B.F.* and Feng, Y.Q. (2018) Single-Nucleotide Resolution Analysis of 5-Hydroxymethylcytosine in DNA by Enzyme-Mediated Deamination in Combination with Sequencing. Anal Chem, 90, 14622-14628.
41. Chu, J.M., Ye, T.T., Ma, C.J., Lan, M.D., Liu, T., Yuan, B.F.* and Feng, Y.Q. (2018) Existence of Internal N7-Methylguanosine Modification in mRNA Determined by Differential Enzyme Treatment Coupled with Mass Spectrometry Analysis. ACS Chem Biol. 13, 3243−3250
42. Jiang, H.P., Xiong, J., Liu, F.L., Ma, C.J., Tang, X.L., Yuan, B.F.* and Feng, Y.Q. (2018) Modified nucleoside triphosphates exist in mammals. Chem Sci, 9, 4160-4167.
43. Yuan, B.F., Zhu, Q.F., Guo, N., Zheng, S.J., Wang, Y.L., Wang, J., Xu, J., Liu, S.J., He, K., Hu, T., Zheng, Y.W., Xu, F.Q. and Feng, Y.Q.* (2018) Comprehensive Profiling of Fecal Metabolome of Mice by Integrated Chemical Isotope Labeling-Mass Spectrometry Analysis. Anal Chem, 90, 3512-3520.
44. Lan, M.D., Xiong, J., You, X.J., Weng, X.C., Zhou, X., Yuan, B.F.* and Feng, Y.Q. (2018) Existence of Diverse Modifications in Small-RNA Species Composed of 16-28 Nucleotides. Chem-Eur J, 24, 9949-9956.
45. Cheng, Q. Y., Xiong, J., Wang, F., Yuan, B.F.*, and Feng, Y. Q. (2018) Chiral derivatization coupled with liquid chromatography/mass spectrometry for determining ketone metabolites of hydroxybutyrate enantiomers, Chin Chem Lett 29, 115-118.
46. Zeng, H., Qi, C.B., Liu, T., Xiao, H.M., Cheng, Q.Y., Jiang, H.P., Yuan, B.F.* and Feng, Y.Q. (2017) Formation and Determination of Endogenous Methylated Nucleotides in Mammals by Chemical Labeling Coupled with Mass Spectrometry Analysis. Anal Chem, 89, 4153-4160.
47. Xiong, J., Liu, X., Cheng, Q.Y., Xiao, S., Xia, L.X., Yuan, B.F.* and Feng, Y.Q. (2017) Heavy Metals Induce Decline of Derivatives of 5-Methycytosine in Both DNA and RNA of Stem Cells. ACS Chem Biol, 12, 1636-1643.
48. Tang, F., Yu, Q.W., Yuan, B.F.* and Feng, Y.Q.* (2017) Hydrophilic materials in sample pretreatment. TrAC-Trend Anal Chem, 86, 172-184.
49. Huang, W., Lan, M.D., Qi, C.B., Zheng, S.J., Wei, S.Z., Yuan, B.F.* and Feng, Y.Q. (2016). Formation and determination of the oxidation products of 5-methylcytosine in RNA. Chem Sci. 2016, 7, 5495-5502.
50. Zhang, H.Y., Xiong, J., Qi, B.L., Feng, Y.Q.* and Yuan, B.F.* (2016) The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals. Chem Commun (Camb), 52, 737-740
51. Huang, W., Qi, C.B., Lv, S.W., Xie, M., Feng, Y.Q.*, Huang, W.H.* and Yuan, B.F.* (2016) Determination of DNA and RNA Methylation in Circulating Tumor Cells by Mass Spectrometry. Anal Chem. 88, 1378-1384.
52. Xu, J., Wu, P., Ye, E.C., Yuan, B.F.* and Feng, Y.Q.* (2016) Metal oxides in sample pretreatment. TrAC-Trend Anal Chem, 80, 41-56.
53. Li, X.S., Yuan, B.F.* and Feng, Y.Q.* (2016) Recent advances in phosphopeptide enrichment: Strategies and techniques. TrAC-Trend Anal Chem, 78, 70-83.
54. Chen, K., Zhang, J., Guo, Z., Ma, Q., Xu, Z., Zhou, Y., Xu, Z., Li, Z., Liu, Y., Ye, X., Li, X., Yuan, B.F., Ke, Y., He, C., Zhou, L., Liu, J. and Ci, W.* (2016) Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. Cell Res, 26, 103-118.
55. Tang, Y., Zheng, S.J., Qi, C.B., Feng, Y.Q.* and Yuan, B.F.* (2015) Sensitive and simultaneous determination of 5-methylcytosine and its oxidation products in genomic DNA by chemical derivatization coupled with liquid chromatography-tandem mass spectrometry analysis. Anal Chem, 87, 3445-3452.
56. Chu, J.M., Qi, C.B., Huang, Y.Q., Jiang, H.P., Hao, Y.H., Yuan, B.F.* and Feng, Y.Q.* (2015) Metal Oxide-Based Selective Enrichment Combined with Stable Isotope Labeling-Mass Spectrometry Analysis for Profiling of Ribose Conjugates. Anal Chem, 87, 7364-7372.
57. Shen, F., Huang, W., Huang, J.T., Xiong, J., Yang, Y., Wu, K., Jia, G.F., Chen, J., Feng, Y.Q.*, Yuan, B.F.*, Liu, S.M.* (2015) Decreased N(6)-Methyladenosine in Peripheral Blood RNA From Diabetic Patients Is Associated With FTO Expression Rather Than ALKBH5. J Clin Endocrinol Metab, 100, E148-154.
58. Li, X.M., Zheng, K.W., Zhang, J.Y., Liu, H.H., He, Y.D., Yuan, B.F., Hao, Y.H. and Tan, Z.* (2015) Guanine-vacancy-bearing G-quadruplexes responsive to guanine derivatives. Proc Natl Acad Sci U S A. 112, 14581-14586
59. Yuan, B.F.* and Feng, Y.Q. (2014) Recent advances in the analysis of 5-methylcytosine and its oxidation products. TrAC-Trend Anal Chem, 54, 24-35.
60. Xing, X.W., Tang, F., Wu, J., Chu, J.M., Feng, Y.Q., Zhou, X.* and Yuan, B.F.* (2014) Sensitive detection of DNA methyltransferase activity based on exonuclease-mediated target recycling. Anal Chem, 86, 11269-11274.
61. Tang, Y., Xiong, J., Jiang, H.P., Zheng, S.J., Feng, Y.Q.* and Yuan, B.F.* (2014) Determination of oxidation products of 5-methylcytosine in plants by chemical derivatization coupled with liquid chromatography/tandem mass spectrometry analysis. Anal Chem, 86, 7764-7772.
62. Qi, B.L., Liu, P., Wang, Q.Y., Cai, W.J., Yuan, B.F.* and Feng, Y.Q.* (2014) Derivatization for liquid chromatography-mass spectrometry. TrAC-Trend Anal Chem, 59, 121-132.
63. Liu, P., Huang, Y.Q., Cai, W.J., Yuan, B.F.* and Feng, Y.Q.* (2014) Profiling of thiol-containing compounds by stable isotope labeling double precursor ion scan mass spectrometry. Anal Chem, 86, 9765-9773.
64. Liang, Q., Dexheimer, T.S., Zhang, P., Rosenthal, A.S., Villamil, M.A., You, C., Zhang, Q., Chen, J., Ott, C.A., Sun, H., Luci, D.K., Yuan, B.F., Simeonov, A., Jadhav, A., Xiao, H., Wang, Y., Maloney, D.J. and Zhuang, Z.* (2014) A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol, 10, 298-304.
65. Wang, S.T., Huang, W., Lu, W., Yuan, B.F.* and Feng, Y.Q.* (2013) TiO2-Based Solid Phase Extraction Strategy for Highly Effective Elimination of Normal Ribonucleosides before Detection of 2'-Deoxynucleosides/Low-Abundance 2'-O-Modified Ribonucleosides. Anal Chem, 85, 10512-10518.
66. Tang, Y., Chu, J.M., Huang, W., Xiong, J., Xing, X.W., Zhou, X., Feng, Y.Q.* and Yuan, B.F.* (2013) Hydrophilic material for the selective enrichment of 5-hydroxymethylcytosine and its liquid chromatography-tandem mass spectrometry detection. Anal Chem, 85, 6129-6135.
67. Chen, M.L., Shen, F., Huang, W., Qi, J.H., Wang, Y., Feng, Y.Q.*, Liu, S.M.* and Yuan, B.F.* (2013) Quantification of 5-Methylcytosine and 5-Hydroxymethylcytosine in Genomic DNA from Hepatocellular Carcinoma Tissues by Capillary Hydrophilic-Interaction Liquid Chromatography/Quadrupole TOF Mass Spectrometry. Clin Chem, 59, 824-832.
68. Chen, M.L., Liu, Y.L., Xing, X.W., Zhou, X., Feng, Y.Q.* and Yuan, B.F.* (2013) Preparation of a Hyper-cross-linked Polymer Monolithic Column and Its Application to the Sensitive Determination of Genomic DNA Methylation. Chem-Eur J, 19, 1035-1041.
69. Cao, Z., Yu, Y., Wu, Y., Hao, P.,… Yuan, B.F., Feng, Y., Huang, W., Xing, X., Zhao, G., Li, X., Li, Y. and Li, W.* (2013) The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun, 4, 2602.
70. Tang, Y., Gao, X.D., Wang, Y., Yuan, B.F.* and Feng, Y.Q.* (2012) Widespread existence of Cytosine methylation in yeast DNA measured by gas chromatography/mass spectrometry. Anal Chem, 84, 7249-7255.
71. You, C., Dai, X., Yuan, B.F., Wang, J., Wang, J., Brooks, P.J., Niedernhofer, L.J. and Wang, Y.* (2012) A quantitative assay for assessing the effects of DNA lesions on transcription. Nat Chem Biol, 8, 817-822.
72. Yuan, B.F., Zhang, J., Wang, H., Xiong, L., Cai, Q., Wang, T., Jacobsen, S., Pradhan, S. and Wang, Y.* (2011) 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1. Cancer Res, 71, 1904-1911.
73. Yuan, B.F., Wang, J., Cao, H., Sun, R. and Wang, Y.* (2011) High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing. Nucleic Acids Res, 39, 5945-5954.
74. Yuan, B.F., You, C., Andersen, N., Jiang, Y., Moriya, M., O'Connor, T.R. and Wang, Y.* (2011) The roles of DNA polymerases kappa and iota in the error-free bypass of N2-carboxyalkyl-2'-deoxyguanosine lesions in mammalian cells. J Biol Chem, 286, 17503-17511.
75. Yuan, B.F., O'Connor, T.R. and Wang, Y.* (2010) 6-Thioguanine and S(6)-Methylthioguanine Are Mutagenic in Human Cells. ACS Chem. Biol., 5, 1021-1027.
76. Yuan, B.F., Jiang, Y. and Wang, Y.* (2010) Efficient formation of the tandem thymine glycol/8-oxo-7,8-dihydroguanine lesion in isolated DNA and the mutagenic and cytotoxic properties of the tandem lesions in Escherichia coli cells. Chem Res Toxicol, 23, 11-19.
77. Yuan, B.F., Cao, H., Jiang, Y., Hong, H. and Wang, Y.* (2008) Efficient and accurate bypass of N2-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo. Proc. Natl. Acad. Sci. U S A., 105, 8679-8684.
78. Yuan, B.F. and Wang, Y.* (2008) Mutagenic and cytotoxic properties of 6-thioguanine, S6-methylthioguanine, and guanine-S6-sulfonic acid. J Biol Chem, 283, 23665-23670.
79. Yuan, B.F., Zhuang, X.Y., Hao, Y.H. and Tan, Z.* (2008) Kinetics of base stacking-aided DNA hybridization. Chem Commun (Camb), 6600-6602.
80. Yuan, B.F., Hao, Y.H. and Tan, Z.* (2004) Universal sensing strategy for the detection of nucleic acid targets by optical biosensor based on surface plasmon resonance. Clin Chem, 50, 1057-1060.
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