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Transition-Metal Catalyzed C−H Alkylation Using Epoxides as Alkylating Reagents

  • 发布时间:2026-06-21
  • 点击次数:
  • 影响因子:4.1
  • DOI码:10.1002/cctc.202301764
  • 发表刊物:ChemCatChem
  • 摘要:The alkylation of arenes is one of the most fundamental transformations in synthetic chemistry and the transition-metal-catalyzed direct C−H alkylation represents a straightforward and attractive approach from both atom and step-economy perspectives. Epoxides, the smallest three-membered saturated O-heterocycles that can be easily prepared in racemic or enantioenriched forms, are highly useful building blocks for the synthesis of complex organic molecules. Owing to their inherent high ring-strain, epoxides readily undergo ring-opening reactions and have been used as alkylating reagents for C−H alkylation catalyzed by transition metals. This review summarizes recent advances in utilizing epoxides as alkylating reagents in transition-metal-catalyzed C−H alkylation as well as their synthetic applications in organic synthesis.
  • 论文类型:期刊论文
  • 学科门类:理学
  • 卷号:16
  • 期号:14
  • 页面范围:e202301764
  • ISSN号:1867-3880
  • 是否译文:
  • 发表时间:2024-07-22
  • 收录刊物:SCI
  • 发布期刊链接:https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cctc.202301764

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