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Quick assembly of 1-alkylidenyl-tetrahydroisoquinolines via a Catellani reaction/NBS-mediated cyclization sequence and synthetic applications

  • 发布时间：2026-06-21
  • 点击次数：
  • 影响因子：9.8
  • DOI码：10.1007/s11426-022-1526-7
  • 发表刊物：Science China-Chemistry
  • 摘要：We herein disclose a modular synthesis of 1-bromomethylene-THIQs involving a Catellani reaction of aryl iodides, aziridines, and terminal alkynes followed by an N-bromosuccinimide (NBS)-mediated cyclization. This approach features mild reaction conditions, wide substrate scope, good step-economy and good scalability. Based on this new method, we have accomplished the concise total synthesis of (±)-cularine, formal synthesis of 8-oxopseudopalmatine as well as the first total synthesis of dactyllactone A, demonstrating the wide synthetic potential of this method.
  • 学科门类：理学
  • 卷号：11
  • 期号：66
  • 页面范围：3136-3140
  • ISSN号：1869-1870
  • 是否译文：否
  • 收录刊物：SCI
  • 发布期刊链接：https://link.springer.com/article/10.1007/s11426-022-1526-7#Sec1

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