Feng Yong
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Personal Information
- Supervisor of Master's Candidates
- Name (Pinyin):Feng Yong
- E-Mail:
- Education Level:研究生毕业
- Business Address:基础医学院1号楼
- Gender:Male
- Contact Information:18627962533； yongfeng@whu.edu.cn
- Teacher College:School of Basic Medical Science
- Discipline:
Pathogenic Organisms;
Microbiology
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CRISPR/Cas9-mediated deletion of miR-146a enhances antiviral response in HIV-1 infected cells
- Date of Publication:2019-06-26
- Hits:
Affiliation of Author(s):
School of Basic Medical Sciences, Wuhan UniversityTeaching and Research Group:
Department of Medical MicrobiologyJournal:
Genes and ImmunityPlace of Publication:
ENGLANDFunded by:
NSFC81271818; NSFC81471940Key Words:
CRISPR/Cas9, miR-146a, HIV-1, antiviral responseAbstract:
The human immunodeficiency virus type 1 (HIV-1) causes persistent infection in human and induces miR-146a expression in infected cells. miR-146a represses the innate immune response by inhibiting the expression of TRAF6 and IRAK1 genes, thus negatively controls the NF-κB-related cytokines and interferon stimulated genes. Here we reported that lentiviral CRISPR/Cas9 system was highly efficient in introducing mutations in the precursor miR-146a genomic sequences, resulting in a loss of miR-146a expression and function.Note:
PMID: 29961753 DOI: 10.1038/s41435-018-0036-xIndexed by:
Journal paperCorrespondence Author:
Hou Wei,Feng YongDiscipline:
MedicineFirst-Level Discipline:
Basic MedicineVolume:
20Issue:
4Page Number:
327-337Translation or Not:
noDate of Publication:
2019-04-30Included Journals:
SCILinks to published journals:
https://www.nature.com/articles/s41435-018-0036-x