Feng Yong
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Personal Information
- Supervisor of Master's Candidates
- Name (Pinyin):Feng Yong
- E-Mail:yongfeng@whu.edu.cn
- Education Level:研究生毕业
- Business Address:基础医学院1号楼
- Gender:Male
- Contact Information:18627962533； yongfeng@whu.edu.cn
- Professional Title:Associate professor
- Discipline:
Pathogenic Organisms;
Microbiology
Other Contact Information
- ZipCode:430071
- PostalAddress:武汉市武昌区东湖路115号，武汉大学基础医学院一号楼
- OfficePhone:027-68759997
- Telephone:18627962533
- email:yongfeng@whu.edu.cn
Drosha processing controls the specificity and efficiency of global microRNA expression
- Date of Publication:2019-06-26
- Hits:
Journal:
Biochim Biophys Acta-Gene Regulatory MechanismsKey Words:
miRNA, Pri-miRNA processing, Drosha, miRNA expression, RNA secondary structureAbstract:
microRNAs (miRNAs) are a large family of approximately 22-nucleotide-long RNAs that regulate gene expression. They are first transcribed as long, primary transcripts, which then undergo a series of processing steps to generate the single-stranded, mature miRNAs. Here, we showed that Drosha cleaved hundreds of human primary miRNA transcript substrates with different efficiencies in vitro. The differential Drosha susceptibility of the primary miRNA transcripts significantly correlated with the expression of the corresponding, mature miRNAs in vivo. Conserved miRNAs were more efficiently expresseIndexed by:
Journal paperDiscipline:
Natural ScienceFirst-Level Discipline:
BiologyVolume:
1809Issue:
11-12Page Number:
700-707Translation or Not:
noDate of Publication:
2011-11-26Included Journals:
SCILinks to published journals:
https://www.sciencedirect.com/science/article/pii/S1874939911000915?via%3Dihub