CRISPR/Cas9-mediated deletion of miR-146a enhances antiviral response in HIV-1 infected cells
发布时间：2019-06-26 点击次数：
所属单位：武汉大学基础医学院
教研室：Department of Medical Microbiology
发表刊物：Genes & Immunity
刊物所在地：ENGLAND
项目来源：国家自然科学基金NSFC81271818; NSFC81471940
关键字：CRISPR/Cas9, miR-146a, HIV-1, antiviral response
摘要：The human immunodeficiency virus type 1 (HIV-1) causes persistent infection in human and induces miR-146a expression in infected cells. miR-146a represses the innate immune response by inhibiting the expression of TRAF6 and IRAK1 genes, thus negatively controls the NF-κB-related cytokines and interferon stimulated genes. Here we reported that lentiviral CRISPR/Cas9 system was highly efficient in introducing mutations in the precursor miR-146a genomic sequences, resulting in a loss of miR-146a expression and function.
备注：PMID: 29961753 DOI: 10.1038/s41435-018-0036-x
论文类型：期刊论文
通讯作者：侯炜,冯勇
学科门类：医学
一级学科：基础医学
卷号：20
期号：4
页面范围：327-337
是否译文：否
发表时间：2019-04-30
收录刊物：SCI
