IFN-λs inhibit Hantaan virus infection through the JAK-STAT pathway and expression of Mx2 protein
发布时间：2019-06-26 点击次数：
发表刊物：Genes & Immunity
摘要：Hantaan virus (HTNV), member of the newly defined Hantaviridae family, within the order Bunyavirales, can cause a hemorrhagic fever with renal syndrome with high fatality rates in humans. However, no specific antiviral agents are currently available for HTNV infection approved by the US Food and Drug Administration. Although interferon lambdas (IFN-λs) have been shown to induce an antiviral state against HTNV, the molecular mechanisms remain to be determined. In this study, we found that IFN-λs exerted its anti-HTNV effect by activating Janus kinase/signal transducers and
论文类型：期刊论文
通讯作者：侯炜,冯勇
学科门类：医学
一级学科：基础医学
卷号：20
期号：3
页面范围：234-244
是否译文：否
发表时间：2019-03-01
收录刊物：SCI
