HIV-1-Induced miR-146a Attenuates Monocyte Migration by Targeting CCL5 in Human Primary Macrophages
发布时间：2019-06-26 点击次数：
所属单位：武汉大学基础医学院
发表刊物：AIDS Res Hum Retroviruses
项目来源：国自然nos. 81271818 and 81471940
关键字：CCL5/RANTES; HIV-1; macrophage; miR-146a; monocyte migration
摘要：MicroRNAs (miRNAs) are widely involved in immune regulation during virus infection. Several studies showed that the expression of miR-146a was increased in human immunodeficiency virus type I (HIV-1)-infected cells, but the definitive function of miR-146a in HIV-1 infection remains obscure. The production of chemokine (C-C motif) ligand 5 (CCL5) in macrophages has been reported to play an important role in HIV/AIDS-associated pathogenesis. In this study, we examined the effects of miR-146a on CCL5 regulation in HIV-1-infected macrophages. Gain and loss of function studies showed that CCL5 migh
论文类型：期刊论文
学科门类：医学
一级学科：基础医学
卷号：34
期号：7
页面范围：580-589
是否译文：否
发表时间：2018-07-26
收录刊物：SCI
