Expression of HIV-encoded microRNA-TAR and its inhibitory effect on viral replication in human primary macrophages
发布时间：2019-06-26 点击次数：
发表刊物：Archives of Virology
项目来源：NSFC81271818, NSFC81471940
摘要：A number of virus-encoded microRNAs have been shown to play important roles in virus replication and virus-host interactions, although the expression and function of miR-TAR-3p derived from the human immunodeficiency virus type 1 (HIV-1) TAR element remain controversial. In this study, miR-TAR-3p was detected in human peripheral blood monocyte-derived macrophages (MDMs) infected by HIV-1. Overexpression of miR-TAR-3p impaired viral replication, while inhibition of miR-TAR-3p enhanced it. Additionally, miR-TAR-3p repressed viral transcription and replication by targeting the TAR element in the
论文类型：期刊论文
学科门类：医学
一级学科：基础医学
卷号：161
期号：5
页面范围：1115–1123
是否译文：否
发表时间：2016-05-26
收录刊物：SCI
