Drosha processing controls the specificity and efficiency of global microRNA expression
发布时间：2019-06-26 点击次数：
发表刊物：Biochim Biophys Acta-Gene Regulatory Mechanisms
关键字：miRNA, Pri-miRNA processing, Drosha, miRNA expression, RNA secondary structure
摘要：microRNAs (miRNAs) are a large family of approximately 22-nucleotide-long RNAs that regulate gene expression. They are first transcribed as long, primary transcripts, which then undergo a series of processing steps to generate the single-stranded, mature miRNAs. Here, we showed that Drosha cleaved hundreds of human primary miRNA transcript substrates with different efficiencies in vitro. The differential Drosha susceptibility of the primary miRNA transcripts significantly correlated with the expression of the corresponding, mature miRNAs in vivo. Conserved miRNAs were more efficiently expresse
论文类型：期刊论文
学科门类：理学
一级学科：生物学
卷号：1809
期号：11-12
页面范围：700-707
是否译文：否
发表时间：2011-11-26
收录刊物：SCI
