标题：
Maternal PM2.5 exposure triggers preterm birth: a cross-sectional study in Wuhan, China
点击次数：
影响因子：
8.69
DOI码：
10.1186/s41256-020-00144-5
所属单位：
Department of Obstetrics, Renmin Hospital of Wuhan University
教研室：
Department of Epidemiology and Health Statistics
发表刊物：
Global Health Research and Policy
刊物所在地：
England
项目来源：
Health Commission of Hubei Province(WJ2017M008.)
关键字：
Preterm birth; Air pollution; LUR model
摘要：
Background:Most of the studies regarding air pollution and preterm birth (PTB) in highly polluted areas have estimated the exposure level based on fixed-site monitoring. However, exposure assessment methods relying on monitors have the potential to cause exposure misclassification due to a lack of spatial variation. In this study, we utilized a land use regression (LUR) model to assess individual exposure, and explored the association between PM2.5 exposure during each time window and the risk of preterm birth in Wuhan city, China.
Methods: Information on 2101 singleton births, which were >= 20 weeks of gestation and born between November 1, 2013 and May 31, 2014; between January 1, 2015 and August 31, 2015, was obtained from the Obstetrics Department in one 3A hospital in Wuhan. Air quality index (AQI) data were accessed from the Wuhan Environmental Protection Bureau website. Individual exposure during pregnancy was assessed by LUR models and Kriging interpolation. Logistic regression analyses were conducted to determine the association between women exposure to PM2.5 and the risk of different subtypes of PTB.
Results: During the study period, the average individual exposure concentration of PM2.5 during the entire pregnancy was 84.54 mu g/m(3). A 10 mu g/m(3) increase of PM2.5 exposure in the first trimester (OR: 1.169; 95% CI: 1.077, 1.262), the second trimester (OR: 1.056; 95% CI: 1.015, 1.097), the third trimester (OR: 1.052; 95% CI: 1.002, 1.101), and the entire pregnancy (OR: 1.263; 95% CI: 1.158, 1.368) was significantly associated with an increased risk of PTB. For the PTB subgroup, the hazard of PM2.5 exposure during pregnancy was stronger for very preterm births (VPTB) than moderate preterm births (MPTB). The first trimester was the most susceptible exposure window. Moreover, women who had less than 9 years of education or who conceived during the cold season tended to be more susceptible to the PM2.5 exposure during pregnancy.
Conclusions: Maternal exposure to PM2.5 increased the risk of PTB, and this risk was stronger for VPTB than for MPTB, especially during the first trimester.
合写作者：
Ren, Zhan,Fan, Cuifang
论文类型：
期刊论文
通讯作者：
Ma, Lu
学科门类：
医学
一级学科：
公共卫生与预防医学
文献类型：
J
卷号：
5
期号：
1
页面范围：
17
ISSN号：
2397-0642
是否译文：
否
发表时间：
2020-05-08
收录刊物：
SCI
发表时间：
2020-05-08
学科：
流行病与卫生统计学
所在单位：公共卫生学院