标题：
Effects of airborne particulate matter on respiratory morbidity in asthmatic children.
点击次数：
影响因子：
4.7
DOI码：
10.2188/jea.JE2007432
发表刊物：
Journal of epidemiology
刊物所在地：
Japen
关键字：
Particulate Matter, Asthma, Peak Expiratory Flow Rate, Respiratory Sounds
摘要：
Background: The effects of airborne particulate matter (PM) are a major human health concern. In this panel study, we evaluated the acute effects of exposure to PM on peak expiratory flow (PEF) and wheezing in children.
Methods: Daily PEF and wheezing were examined in 19 asthmatic children who were hospitalized in a suburban city in Japan for approximately 5 months. The concentrations of PM less than 2.5 µm in diameter (PM2.5) were monitored at a monitoring station proximal to the hospital. Moreover, PM2.5 concentrations inside and outside the hospital were measured using the dust monitor with a laser diode (PM2.5(LD)). The changes in PEF and wheezing associated with PM concentration were analyzed.
Results: The changes in PEF in the morning and evening were significantly associated with increases in the
average concentration of indoor PM2.5(LD) 24 h prior to measurement (-2.86 L/min [95%CI: -4.12, -1.61] and -3.59L/min [95%CI: -4.99, -2.20] respectively, for 10-µg/m3 increases). The change in PEF was also significantly associated with outdoor PM2.5(LD) concentrations, but the changes were smaller than those observed for indoorPM2.5(LD). Changes in PEF and concentration of stationary-site PM2.5 were not associated. The prevalence of wheezing in the morning and evening were also significantly associated with indoor PM2.5(LD) concentrations (odds ratios = 1.014 [95%CI: 1.006, 1.023] and 1.025 [95%CI: 1.013, 1.038] respectively, for 10-µg/m3 increases). Wheezing in the evening was significantly associated with outdoor PM2.5(LD) concentration. The effects of indoor and outdoor PM2.5(LD) remained significant even after adjusting for ambient nitrogen dioxide concentrations.
Conclusion: Indoor and outdoor PM2.5(LD) concentrations were associated with PEF and wheezing among asth_x005fmatic children. Indoor PM2.5(LD) had a more marked effect than outdoor PM2.5(LD) or stationary-site PM2.5.
合写作者：
Yoshiko Yoda,Masayuki Shima
论文类型：
期刊论文
通讯作者：
Toshiyuki Nishimuta
学科门类：
医学
文献类型：
J
卷号：
18
期号：
3
页面范围：
97-110
字数：
8380
ISSN号：
0917-5040
是否译文：
否
发表时间：
2008-05-16
收录刊物：
SCI
发表时间：
2008-05-16
学科：
流行病与卫生统计学
所在单位：公共卫生学院