研究领域
1. 环境表观遗传学（Environmental epigenetics）
核酸表观遗传修饰在基因调控等方面发挥着重要作用，并在癌症等多种疾病的发生中扮演关键角色。我们的研究致力于通过建立质谱技术和测序技术等高灵敏、特异性的分析方法，深入研究核酸表观遗传修饰的生理功能。同时，我们还探索环境因素对表观遗传修饰的影响和机制，以期为相关疾病的预防和治疗提供新的策略和认识。
2. 代谢组学（Metabolomics）
开发基于质谱技术的代谢组学研究方法，并结合相应的生物学手段，发现疾病的生物标志物，探索代谢物在疾病发生和发展过程中的生理功能，并深入研究环境因素对生命代谢的影响和机制，为相关疾病的预防、诊断和治疗提供新的策略和认识。
3. 环境污染物分析与健康效应研究（Investigation of Environmental Pollutants and Their Impact on Health）
开发高灵敏度和高覆盖率的环境污染物检测新技术，探讨环境污染物对人类健康的影响。通过对暴露组和健康效应进行关联分析，揭示对人类健康产生重要影响的关键环境因素。
项目
国家自然科学基金面上项目，腺嘌呤脱氨酶介导的RNA和DNA中N6-甲基腺嘌呤单碱基分辨率测序分析技术，2023/01-2026/12，主持。
国家自然科学基金面上项目，基于质谱技术的DNA去甲基化新机制研究，2021/01-2024/12，主持。
国家重点研发计划，主要环境污染物对个体发育和代谢的影响及关键机制研究，2023/01-2027/12，项目骨干。
国家重点研发计划，复杂生物体系代谢组的高通量超灵敏定性定量分析技术研究，2023/01-2027/12，项目骨干。
国家自然科学基金优秀青年基金，基于质谱技术的核酸修饰研究，2016/01-2018/12，主持。
湖北省重点研发计划，2023BCB094，妊娠期高血压的早期诊断与预测新技术新产品研发，2023/07-2025/12，主持。
代表性学术成果
1. Wang, M., Xie, N.B., Gang, F.Y., Zhang, S., Zeng, L., Ji, T.T., Xiong, J., Guo, X., Hao, Y., Liu, Y., and Yuan, B.F.* (2024) Bisulfite-Free Whole-Genome Mapping of 5-Methylcytosine at Single-Base Resolution by NTD-seq. Sci China Life Sci, DOI:10.1007/s11427-024-2702-8.
2. Xiong, J., Wu, J., Liu, Y., Feng, Y.J. and Yuan, B.F.* (2024) Quantification and mapping of RNA modifications. TrAC-Trend Anal Chem, 172, 117606.
3. Xie, N.B., Wang, M., Ji, T.T., Guo, X., Gang, F.Y., Hao, Y., Zeng, L., Wang, Y.F., Feng, Y.Q. and Yuan, B.F.* (2024) Simultaneous detection of 5-methylcytosine and 5-hydroxymethylcytosine at specific genomic loci by engineered deaminase-assisted sequencing. Chem Sci, 15, 10073-10083.
4. Min, Y.H., Shao, W.X., Hu, Q.S., Xie, N.B., Zhang, S., Feng, Y.Q., Xing, X.W.* and Yuan, B.F.* (2024) Simultaneous Detection of Adenosine-to-Inosine Editing and N(6)-Methyladenosine at Identical RNA Sites through Deamination-Assisted Reverse Transcription Stalling. Anal Chem, 96, 8730-8739.
5. Gu, Y.H., Chen, Y., Li, Q., Xie, N.B., Xing, X., Xiong, J., Hu, M., Li, T.Z., Yuan, K.Y., Liu, Y., Tang, T.*, He, F.* and Yuan, B.F.* (2024) Metabolome profiling by widely-targeted metabolomics and biomarker panel selection using machine-learning for patients in different stages of chronic kidney disease. Chin Chem Lett, 35, 109627.
6. Xiong, J., Chen, K.K., Xie, N.B., Chen, W., Shao, W.X., Ji, T.T., Yu, S.Y., Feng, Y.Q. and Yuan, B.F.* (2024) Demethylase-assisted site-specific detection of N1-methyladenosine in RNA. Chin Chem Lett, 35, 108953.
7. Ding, J.H., Li, G., Xiong, J., Liu, F.L., Xie, N.B., Ji, T.T., Wang, M., Guo, X., Feng, Y.Q., Ci, W.* and Yuan, B.F.* (2024) Whole-Genome Mapping of Epigenetic Modification of 5-Formylcytosine at Single-Base Resolution by Chemical Labeling Enrichment and Deamination Sequencing. Anal Chem, 96, 4726-4735.
8. Guo, X., Xie, N.B., Chen, W., Ji, T.T., Xiong, J., Feng, T., Wang, M., Zhang, S., Gu, S.Y., Feng, Y.Q.* and Yuan, B.F.* (2024) AlkB-Facilitated Demethylation Enables Quantitative and Site-Specific Detection of Dual Methylation of Adenosine in RNA. Anal Chem, 96, 847-855.
9. Feng, T., Gao, Y.L., Hu, D., Yuan, K.Y., Gu, S.Y., Gu, Y.H., Yu, S.Y., Xiong, J., Feng, Y.Q., Wang, J.* and Yuan, B.F.* (2024) Chronic sleep deprivation induces alterations in DNA and RNA modifications by liquid chromatography-mass spectrometry analysis. Chin Chem Lett, 35, 109259.
10. Chen, Y.Y., Gui, Z., Hu, D., Chen, M.Y., He, J.G., Yu, S.Y., Feng, Y.Q., Wang, J. and Yuan, B.F.* (2024) Adolescent alcohol exposure changes RNA modifications in adult brain by mass spectrometry-based comprehensive profiling analysis. Chin Chem Lett, 34, 108522.
11. Xie, N.B., Wang, M., Chen, W., Ji, T.T., Guo, X., Gang, F.Y., Wang, Y.F., Feng, Y.Q., Liang, Y.,* Ci, W.,* and Yuan, B.F.* (2023) Whole-Genome Sequencing of 5‑Hydroxymethylcytosine at Base Resolution by Bisulfite-Free Single-Step Deamination with Engineered Cytosine Deaminase, ACS Cent Sci, 9, 2315-2325.
12. Ma, C.J., Li, G., Shao, W.X., Min, Y.H., Wang, P., Ding, J.H., Xie, N.B., Wang, M., Tang, F., Feng, Y.Q., Ci, W.,* Wang, Y.,* and Yuan, B.F.* (2023) Single-Nucleotide Resolution Mapping of N6‑Methyladenine in Genomic DNA. ACS Cent Sci, 9, 1799-1809.
13. Shao, W.X., Min, Y.H., Chen, W., Xiong, J., Guo, X., Xie, N.B., Zhang, S., Yu, S.Y., Xie, C., Feng, Y.Q. and Yuan, B.F.* (2023) Single-Base Resolution Detection of N(6)-Methyladenosine in RNA by Adenosine Deamination Sequencing. Anal Chem, 95, 10588-10594.
14. Ji, T.T., Xie, N.B., Ding, J.H., Wang, M., Guo, X., Chen, Y.Y., Yu, S.Y., Feng, Y.Q. and Yuan, B.F.* (2023) Enzymatic Cleavage-Mediated Extension Stalling Enables Accurate Recognition and Quantification of Locus-Specific Uracil Modification in DNA. Anal Chem, 95, 8384-8392.
15. Wang, M., Xie, N.B., Chen, K.K., Ji, T.T., Xiong, J., Guo, X., Yu, S.Y., Tang, F., Xie, C., Feng, Y.Q. and Yuan, B.F.* (2023) Engineered APOBEC3C Sequencing Enables Bisulfite-Free and Direct Detection of DNA Methylation at a Single-Base Resolution. Anal Chem, 95, 1556-1565.
16. Ding, J.H., Chen, M.Y., Xie, N.B., Xie, C., Xiong, N., He, J.G., Wang, J., Guo, C., Feng, Y.Q. and Yuan, B.F.* (2023) Quantitative and site-specific detection of inosine modification in RNA by acrylonitrile labeling-mediated elongation stalling. Biosens Bioelectron, 219, 114821.
17. Tao, W.B., Xie, N.B., Cheng, Q.Y., Feng, Y.Q. and Yuan, B.F.* (2023) Sensitive determination of inosine RNA modification in single cell by chemical derivatization coupled with mass spectrometry analysis. Chin Chem Lett, 34, 108243.
18. Xiong, J., Wang, P., Shao, W.X., Li, G.J., Ding, J.H., Xie, N.B., Wang, M., Cheng, Q.Y., Xie, C.H., Feng, Y.Q., Ci, W.M.* and Yuan, B.F.* (2022) Genome-wide mapping of N-4-methylcytosine at single-base resolution by APOBEC3A-mediated deamination sequencing. Chem Sci, 13, 9960-9972.
19. Xiong, J., Chen, K.K., Xie, N.B., Ji, T.T., Yu, S.Y., Tang, F., Xie, C., Feng, Y.Q. and Yuan, B.F.* (2022) Bisulfite-Free and Single-Base Resolution Detection of Epigenetic DNA Modification of 5-Methylcytosine by Methyltransferase-Directed Labeling with APOBEC3A Deamination Sequencing. Anal Chem, 94, 15489-15498.
20. You, X.J., Zhang, S., Chen, J.J., Tang, F., He, J., Wang, J., Qi, C.B., Feng, Y.Q., Yuan, B.F.* (2022) Formation and removal of 1,N6-dimethyladenosine in mammalian transfer RNA. Nucleic Acids Res. 50, 9858-9872.
21. Tang, F., Yuan, J., Yuan, B.F.* and Wang, Y.* (2022) DNA−Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol. J Am Chem Soc, 144, 454-462.
22. Chen, J.J., You, X.J., Li, L., Xie, N.B., Ding, J.H., Yuan, B.F.* and Feng, Y.Q. (2022) Single-Base Resolution Detection of Adenosine-to-Inosine RNA Editing by Endonuclease-Mediated Sequencing. Anal Chem, 94, 8740-8747..
23. Xie, N.B., Wang, M., Ji, T.T., Guo, X., Ding, J.H., Yuan, B.F.* and Feng, Y.Q. (2022) Bisulfite-free and single-nucleotide resolution sequencing of DNA epigenetic modification of 5-hydroxymethylcytosine using engineered deaminase. Chem Sci, 13, 7046–7056.
24. Feng, Y.J., You, X.J., Ding, J.H., Zhang, Y.F., Yuan, B.F.* and Feng, Y.Q. (2022) Identification of Inosine and 2'-O-Methylinosine Modifications in Yeast Messenger RNA by Liquid Chromatography-Tandem Mass Spectrometry Analysis. Anal Chem, 94, 4747-4755.
25. Chen, M.Y., Qi, C.B., Tang, X.M., Ding, J.H., Yuan, B.F.* and Feng, Y.Q. (2022) Comprehensive profiling and evaluation of the alteration of RNA modifications in thyroid carcinoma by liquid chromatography-tandem mass spectrometry. Chin Chem Lett, 33, 3772-3776.
26. Chen, M.Y., Gui, Z., Chen, K.K., Ding, J.H., He, J.G., Xiong, J., Li, J.L., Wang, J., Yuan, B.F.* and Feng, Y.Q. (2022) Adolescent alcohol exposure alters DNA and RNA modifications in peripheral blood by liquid chromatography-tandem mass spectrometry analysis. Chin Chem Lett, 33, 2086-2090.
27. Ma, C.J., Li, L., Shao, W.X., Ding, J.H., Cai, X., Lun, Z., Yuan, B.F.* and Feng, Y.Q. (2021) Enzyme-mediated bioorthogonal labeling method for genome-wide mapping of 5-hydroxymethyluracil. Chem Sci, 12, 14126-14132.
28. Feng, Y., Chen, J.J., Xie, N.B., Ding, J.H., You, X.J., Tao, W.B., Zhang, X., Yi, C., Zhou, X., Yuan, B.F.* and Feng, Y.Q. (2021) Direct decarboxylation of Ten-eleven translocation-produced 5-carboxylcytosine in mammalian genomes forms a new mechanism for active DNA demethylation. Chem Sci, 12, 11322-11329.
29. Cheng, M.Y., You, X.J., Ding, J.H., Dai, Y., Chen, M.Y., Yuan, B.F.* and Feng, Y.Q. (2021) Novel dual methylation of cytidines in RNA of mammals. Chem Sci, 12, 8149–8156.
30. Dai, Y., Yuan, B.F.* and Feng, Y.Q. (2021) Quantification and mapping of DNA modifications. RSC Chem Biol, 2, 1096–1114.
31. Dai, Y., Qi, C.B., Feng, Y., Cheng, Q.Y., Liu, F.L., Cheng, M.Y., Yuan, B.F.* and Feng, Y.Q. (2021) Sensitive and Simultaneous Determination of Uridine Thiolation and Hydroxylation Modifications in Eukaryotic RNA by Derivatization Coupled with Mass Spectrometry Analysis. Anal Chem. 93, 6938-6946.
32. Liu, F.L., Ye, T.T., Ding, J.H., Yin, X.M., Yang, X.K., Huang, W.H., Yuan, B.F.* and Feng, Y.Q. (2021) Chemical Tagging Assisted Mass Spectrometry Analysis Enables Sensitive Determination of Phosphorylated Compounds in a Single Cell. Anal Chem, 93, 6848-6856.
33. Wang, Q., Ding, J.H., Xiong, J., Feng, Y., Yuan, B.F.* and Feng, Y.Q. (2021) Site-specific quantification of 5-carboxylcytosine in DNA by chemical conversion coupled with ligation-based PCR. Chin Chem Lett, 32, 3426-3430.
34. Jeschke, J., Collignon, E., Al Wardi, C., Krayem, M., … Yuan, B.F., Willard-Gallo, K., Sotiriou, C., Marine, J.C. and Fuks, F.* (2021) Downregulation of the FTO m(6)A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors. Nat Cancer, 2, 611-628.
35. Feng, Y., Xie, N.B., Tao, W.B., Ding, J.H., You, X.J., Ma, C.J., Zhang, X., Yi, C., Zhou, X., Yuan, B.F.* and Feng, Y.Q. (2020) Transformation of 5-Carboxylcytosine to Cytosine Through C–C Bond Cleavage in Human Cells Constitutes a Novel Pathway for DNA Demethylation. CCS Chem, 2, 994-1008.
36. Cheng, Q.Y., Xiong, J., Ma, C.J., Dai, Y., Ding, J.H., Liu, F.L., Yuan, B.F.* and Feng, Y. Q. (2020) Chemical tagging for sensitive determination of uridine modifications in RNA, Chem Sci, 11, 1878-1891.
37. Ding, J.H., Ma, C.J., Chen, M.Y., Chen, B., Yuan, B.F.* and Feng, Y.Q. (2020) Quantification and single-base resolution analysis of N1-methyladenosine in mRNA by ligation-assisted differentiation. Anal Chem, 92, 2612-2619.
38. Liu, F.L, Qi, C.B., Cheng, Q.Y., Ding, J.H., Yuan, B.F.* and Feng, Y.Q. (2020) Diazo reagent labeling with mass spectrometry analysis for sensitive determination of ribonucleotides in living organisms. Anal Chem, 92, 2301-2309.
39. Lan, J., Rajan, N., Bizet, M., Penning, A.,… Yuan, B.F. and Fuks, F.* (2020) Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation. Nat Commun, 11, 4956.
40. You, X.J., Liu, T., Ma, C.J., Qi, C.B., Tong, Y., Zhao, X., Yuan, B.F.* and Feng, Y.Q. (2019) Determination of RNA hydroxylmethylation in mammals by mass spectrometry analysis. Anal Chem, 91, 10477-10483.
41. Tang, F., Liu, S., Li, Q.Y., Yuan, J., Li, L., Wang, Y., Yuan, B.F.* and Feng, Y.Q. (2019) Location analysis of 8-oxo-7,8-dihydroguanine in DNA by polymerase-mediated differential coding. Chem Sci, 10, 4272–4281.
42. Xiong, J., Ye, T.T., Ma, C.J., Cheng, Q.Y., Yuan, B.F.* and Feng, Y.Q. (2019) N6-Hydroxymethyladenine: a hydroxylation derivative of N6-methyladenine in genomic DNA of mammals. Nucleic Acids Res, 47, 1268-1277.
43. Chen, B., Yuan, B.F.* and Feng, Y.Q. (2019) Analytical Methods for Deciphering RNA Modifications. Anal Chem, 91, 743-756.
44. Xu, J., Zhang, Q.F., Zheng, J., Yuan, B.F.* and Feng, Y.Q.* (2019) Mass spectrometry-based fecal metabolome analysis. TrAC-Trend Anal Chem, 112, 161-174.
45. Ma, C.J., Ding, J.H., Ye, T.T., Yuan, B.F.* and Feng, Y.Q. (2019) AlkB Homologue 1 Demethylates N(3)-Methylcytidine in mRNA of Mammals. ACS Chem Biol, 14, 1418-1425.
46. Qi, C.B., Jiang, H.P., Xiong, J., Yuan, B.F.*, and Feng, Y.Q. (2019) On-line trapping/capillary hydrophilic-interaction liquid chromatography/mass spectrometry for sensitive determination of RNA modifications from human blood. Chin Chem Lett, 30, 553-557.
47. Qi, C.B., Ding, J.H., Yuan, B.F.*, and Feng, Y.Q. (2019) Analytical methods for locating modifications in nucleic acids. Chin Chem Lett, 30, 1618-1626.
48. Lan, M.D., Yuan, B.F.*, and Feng, Y.Q. (2019) Deciphering nucleic acid modifications by chemical derivatization-mass spectrometry analysis. Chin Chem Lett, 30, 1-6.
49. Li, Q.Y., Xie, N.B., Xiong, J., Yuan, B.F.* and Feng, Y.Q. (2018) Single-Nucleotide Resolution Analysis of 5-Hydroxymethylcytosine in DNA by Enzyme-Mediated Deamination in Combination with Sequencing. Anal Chem, 90, 14622-14628.
50. Chu, J.M., Ye, T.T., Ma, C.J., Lan, M.D., Liu, T., Yuan, B.F.* and Feng, Y.Q. (2018) Existence of Internal N7-Methylguanosine Modification in mRNA Determined by Differential Enzyme Treatment Coupled with Mass Spectrometry Analysis. ACS Chem Biol. 13, 3243−3250
51. Jiang, H.P., Xiong, J., Liu, F.L., Ma, C.J., Tang, X.L., Yuan, B.F.* and Feng, Y.Q. (2018) Modified nucleoside triphosphates exist in mammals. Chem Sci, 9, 4160-4167.
52. Yuan, B.F., Zhu, Q.F., Guo, N., Zheng, S.J., Wang, Y.L., Wang, J., Xu, J., Liu, S.J., He, K., Hu, T., Zheng, Y.W., Xu, F.Q. and Feng, Y.Q.* (2018) Comprehensive Profiling of Fecal Metabolome of Mice by Integrated Chemical Isotope Labeling-Mass Spectrometry Analysis. Anal Chem, 90, 3512-3520.
53. Lan, M.D., Xiong, J., You, X.J., Weng, X.C., Zhou, X., Yuan, B.F.* and Feng, Y.Q. (2018) Existence of Diverse Modifications in Small-RNA Species Composed of 16-28 Nucleotides. Chem-Eur J, 24, 9949-9956.
54. Cheng, Q. Y., Xiong, J., Wang, F., Yuan, B.F.*, and Feng, Y. Q. (2018) Chiral derivatization coupled with liquid chromatography/mass spectrometry for determining ketone metabolites of hydroxybutyrate enantiomers, Chin Chem Lett 29, 115-118.
55. Zeng, H., Qi, C.B., Liu, T., Xiao, H.M., Cheng, Q.Y., Jiang, H.P., Yuan, B.F.* and Feng, Y.Q. (2017) Formation and Determination of Endogenous Methylated Nucleotides in Mammals by Chemical Labeling Coupled with Mass Spectrometry Analysis. Anal Chem, 89, 4153-4160.
56. Xiong, J., Liu, X., Cheng, Q.Y., Xiao, S., Xia, L.X., Yuan, B.F.* and Feng, Y.Q. (2017) Heavy Metals Induce Decline of Derivatives of 5-Methycytosine in Both DNA and RNA of Stem Cells. ACS Chem Biol, 12, 1636-1643.
57. Tang, F., Yu, Q.W., Yuan, B.F.* and Feng, Y.Q.* (2017) Hydrophilic materials in sample pretreatment. TrAC-Trend Anal Chem, 86, 172-184.
58. Huang, W., Lan, M.D., Qi, C.B., Zheng, S.J., Wei, S.Z., Yuan, B.F.* and Feng, Y.Q. (2016). Formation and determination of the oxidation products of 5-methylcytosine in RNA. Chem Sci. 2016, 7, 5495-5502.
59. Zhang, H.Y., Xiong, J., Qi, B.L., Feng, Y.Q.* and Yuan, B.F.* (2016) The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals. Chem Commun (Camb), 52, 737-740
60. Huang, W., Qi, C.B., Lv, S.W., Xie, M., Feng, Y.Q.*, Huang, W.H.* and Yuan, B.F.* (2016) Determination of DNA and RNA Methylation in Circulating Tumor Cells by Mass Spectrometry. Anal Chem. 88, 1378-1384.
61. Xu, J., Wu, P., Ye, E.C., Yuan, B.F.* and Feng, Y.Q.* (2016) Metal oxides in sample pretreatment. TrAC-Trend Anal Chem, 80, 41-56.
62. Li, X.S., Yuan, B.F.* and Feng, Y.Q.* (2016) Recent advances in phosphopeptide enrichment: Strategies and techniques. TrAC-Trend Anal Chem, 78, 70-83.
63. Chen, K., Zhang, J., Guo, Z., Ma, Q., Xu, Z., Zhou, Y., Xu, Z., Li, Z., Liu, Y., Ye, X., Li, X., Yuan, B.F., Ke, Y., He, C., Zhou, L., Liu, J. and Ci, W.* (2016) Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. Cell Res, 26, 103-118.
64. Tang, Y., Zheng, S.J., Qi, C.B., Feng, Y.Q.* and Yuan, B.F.* (2015) Sensitive and simultaneous determination of 5-methylcytosine and its oxidation products in genomic DNA by chemical derivatization coupled with liquid chromatography-tandem mass spectrometry analysis. Anal Chem, 87, 3445-3452.
65. Chu, J.M., Qi, C.B., Huang, Y.Q., Jiang, H.P., Hao, Y.H., Yuan, B.F.* and Feng, Y.Q.* (2015) Metal Oxide-Based Selective Enrichment Combined with Stable Isotope Labeling-Mass Spectrometry Analysis for Profiling of Ribose Conjugates. Anal Chem, 87, 7364-7372.
66. Shen, F., Huang, W., Huang, J.T., Xiong, J., Yang, Y., Wu, K., Jia, G.F., Chen, J., Feng, Y.Q.*, Yuan, B.F.*, Liu, S.M.* (2015) Decreased N(6)-Methyladenosine in Peripheral Blood RNA From Diabetic Patients Is Associated With FTO Expression Rather Than ALKBH5. J Clin Endocrinol Metab, 100, E148-154.
67. Li, X.M., Zheng, K.W., Zhang, J.Y., Liu, H.H., He, Y.D., Yuan, B.F., Hao, Y.H. and Tan, Z.* (2015) Guanine-vacancy-bearing G-quadruplexes responsive to guanine derivatives. Proc Natl Acad Sci U S A. 112, 14581-14586
68. Yuan, B.F.* and Feng, Y.Q. (2014) Recent advances in the analysis of 5-methylcytosine and its oxidation products. TrAC-Trend Anal Chem, 54, 24-35.
69. Xing, X.W., Tang, F., Wu, J., Chu, J.M., Feng, Y.Q., Zhou, X.* and Yuan, B.F.* (2014) Sensitive detection of DNA methyltransferase activity based on exonuclease-mediated target recycling. Anal Chem, 86, 11269-11274.
70. Tang, Y., Xiong, J., Jiang, H.P., Zheng, S.J., Feng, Y.Q.* and Yuan, B.F.* (2014) Determination of oxidation products of 5-methylcytosine in plants by chemical derivatization coupled with liquid chromatography/tandem mass spectrometry analysis. Anal Chem, 86, 7764-7772.
71. Qi, B.L., Liu, P., Wang, Q.Y., Cai, W.J., Yuan, B.F.* and Feng, Y.Q.* (2014) Derivatization for liquid chromatography-mass spectrometry. TrAC-Trend Anal Chem, 59, 121-132.
72. Liu, P., Huang, Y.Q., Cai, W.J., Yuan, B.F.* and Feng, Y.Q.* (2014) Profiling of thiol-containing compounds by stable isotope labeling double precursor ion scan mass spectrometry. Anal Chem, 86, 9765-9773.
73. Liang, Q., Dexheimer, T.S., Zhang, P., Rosenthal, A.S., Villamil, M.A., You, C., Zhang, Q., Chen, J., Ott, C.A., Sun, H., Luci, D.K., Yuan, B.F., Simeonov, A., Jadhav, A., Xiao, H., Wang, Y., Maloney, D.J. and Zhuang, Z.* (2014) A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol, 10, 298-304.
74. Wang, S.T., Huang, W., Lu, W., Yuan, B.F.* and Feng, Y.Q.* (2013) TiO2-Based Solid Phase Extraction Strategy for Highly Effective Elimination of Normal Ribonucleosides before Detection of 2'-Deoxynucleosides/Low-Abundance 2'-O-Modified Ribonucleosides. Anal Chem, 85, 10512-10518.
75. Tang, Y., Chu, J.M., Huang, W., Xiong, J., Xing, X.W., Zhou, X., Feng, Y.Q.* and Yuan, B.F.* (2013) Hydrophilic material for the selective enrichment of 5-hydroxymethylcytosine and its liquid chromatography-tandem mass spectrometry detection. Anal Chem, 85, 6129-6135.
76. Chen, M.L., Shen, F., Huang, W., Qi, J.H., Wang, Y., Feng, Y.Q.*, Liu, S.M.* and Yuan, B.F.* (2013) Quantification of 5-Methylcytosine and 5-Hydroxymethylcytosine in Genomic DNA from Hepatocellular Carcinoma Tissues by Capillary Hydrophilic-Interaction Liquid Chromatography/Quadrupole TOF Mass Spectrometry. Clin Chem, 59, 824-832.
77. Chen, M.L., Liu, Y.L., Xing, X.W., Zhou, X., Feng, Y.Q.* and Yuan, B.F.* (2013) Preparation of a Hyper-cross-linked Polymer Monolithic Column and Its Application to the Sensitive Determination of Genomic DNA Methylation. Chem-Eur J, 19, 1035-1041.
78. Cao, Z., Yu, Y., Wu, Y., Hao, P.,… Yuan, B.F., Feng, Y., Huang, W., Xing, X., Zhao, G., Li, X., Li, Y. and Li, W.* (2013) The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun, 4, 2602.
79. Tang, Y., Gao, X.D., Wang, Y., Yuan, B.F.* and Feng, Y.Q.* (2012) Widespread existence of Cytosine methylation in yeast DNA measured by gas chromatography/mass spectrometry. Anal Chem, 84, 7249-7255.
80. You, C., Dai, X., Yuan, B.F., Wang, J., Wang, J., Brooks, P.J., Niedernhofer, L.J. and Wang, Y.* (2012) A quantitative assay for assessing the effects of DNA lesions on transcription. Nat Chem Biol, 8, 817-822.
81. Yuan, B.F., Zhang, J., Wang, H., Xiong, L., Cai, Q., Wang, T., Jacobsen, S., Pradhan, S. and Wang, Y.* (2011) 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1. Cancer Res, 71, 1904-1911.
82. Yuan, B.F., Wang, J., Cao, H., Sun, R. and Wang, Y.* (2011) High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing. Nucleic Acids Res, 39, 5945-5954.
83. Yuan, B.F., You, C., Andersen, N., Jiang, Y., Moriya, M., O'Connor, T.R. and Wang, Y.* (2011) The roles of DNA polymerases kappa and iota in the error-free bypass of N2-carboxyalkyl-2'-deoxyguanosine lesions in mammalian cells. J Biol Chem, 286, 17503-17511.
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89. Yuan, B.F., Hao, Y.H. and Tan, Z.* (2004) Universal sensing strategy for the detection of nucleic acid targets by optical biosensor based on surface plasmon resonance. Clin Chem, 50, 1057-1060.
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