Feng Yong
+
Personal Information
- Supervisor of Master's Candidates
- Name (Pinyin):Feng Yong
- E-Mail:
- Education Level:研究生毕业
- Business Address:基础医学院1号楼
- Gender:Male
- Contact Information:18627962533； yongfeng@whu.edu.cn
- Teacher College:School of Basic Medical Science
- Discipline:
Pathogenic Organisms;
Microbiology
Other Contact Information
- ZipCode:
- PostalAddress:
- OfficePhone:
- Telephone:
- email:
HIV-1-Induced miR-146a Attenuates Monocyte Migration by Targeting CCL5 in Human Primary Macrophages
- Date of Publication:2019-06-26
- Hits:
Affiliation of Author(s):
武汉大学基础医学院Journal:
AIDS Res Hum RetrovirusesFunded by:
国自然nos. 81271818 and 81471940Key Words:
CCL5/RANTES; HIV-1; macrophage; miR-146a; monocyte migrationAbstract:
MicroRNAs (miRNAs) are widely involved in immune regulation during virus infection. Several studies showed that the expression of miR-146a was increased in human immunodeficiency virus type I (HIV-1)-infected cells, but the definitive function of miR-146a in HIV-1 infection remains obscure. The production of chemokine (C-C motif) ligand 5 (CCL5) in macrophages has been reported to play an important role in HIV/AIDS-associated pathogenesis. In this study, we examined the effects of miR-146a on CCL5 regulation in HIV-1-infected macrophages. Gain and loss of function studies showed that CCL5 mighIndexed by:
Journal paperDiscipline:
MedicineFirst-Level Discipline:
Basic MedicineVolume:
34Issue:
7Page Number:
580-589Translation or Not:
noDate of Publication:
2018-07-26Included Journals:
SCILinks to published journals:
https://www.liebertpub.com/doi/full/10.1089/AID.2017.0217?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed