Chaotropic Effect-Induced Sol–Gel Transition and Radical Stabilization for Bacterially Sensitive Near-Infrared Photothermal Therapy
发布时间：2024-04-08
点击次数：
DOI码：10.1021/acs.nanolett.4c00860
发表刊物：Nano Letters
刊物所在地：美国
摘要：Deep-seated bacterial infections (DBIs) are stubborn and deeply penetrate tissues. Eliminating deep-seated bacteria and promoting tissue regeneration remain great challenges. Here, a novel radical-containing hydrogel (SFT-B Gel) cross-linked by a chaotropic effect was designed for the sensing of DBIs and near-infrared photothermal therapy (NIR-II PTT). A silk fibroin solution stained with 4,4′,4″-(1,3,5-triazine-2,4,6-triyl)tris(1-methylpyridin-1-ium) (TPT3+) was employed as the backbone, which could be cross-linked by a closo-dodecaborate cluster (B12H122–) through a chaotropic effect to form the SFT-B Gel. More interestingly, the SFT-B Gel exhibited the ability to sense DBIs, which could generate a TPT2+• radical with obvious color changes in the presence of bacteria. The radical-containing SFT-B Gel (SFT-B★ Gel) possessed strong NIR-II absorption and a remarkable photothermal effect, thus demonstrating excellent NIR-II PTT antibacterial activity for the treatment of DBIs. This work provides a new approach for the construction of intelligent hydrogels with unique properties using a chaotropic effect.
论文类型：期刊论文
论文编号：10.1021/acs.nanolett.4c00860
是否译文：否
发表时间：2024-04-08
收录刊物：SCI