张海波

 硕士生导师 博士生导师

个人信息

性别:男
毕业院校:武汉大学
学历:研究生毕业
在职信息:在职
所在单位:化学与分子科学学院

Applications of Boron Cluster Supramolecular Frameworks as Metal-Free Chemodynamic Therapy Agents for Melanoma

发表时间:2023-09-28 点击次数:
影响因子:13.0
DOI码:10.1002/smll.202307029
发表刊物:Small
摘要:Chemodynamic therapy (CDT) is a highly targeted approach to treat cancer since it converts hydrogen peroxide into harmful hydroxyl radicals (OH·) through Fenton or Fenton-like reactions. However, the systemic toxicity of metal-based CDT agents has limited their clinical applications. Herein, a metal-free CDT agent: 2,4,6-tri(4-pyridyl)-1,3,5-triazine (TPT)/ [closo-B 12 H 12 ] 2− (TPT@ B 12 H 12) is reported. Compared to the traditional metal-based CDT agents, TPT@B 12 H 12 is free of metal avoiding cumulative toxicity during long-term therapy. Density functional theory (DFT) calculation revealed that TPT@B 12 H 12 decreased the activation barrier more than 3.5 times being a more effective catalyst than the Fe 2+ ion (the Fenton reaction), which decreases the barrier about twice. Mechanismly, the theory calculation indicated that both [B 12 H 12 ] −· and [TPT-H] 2+ have the capacity to decompose hydrogen into 1 O 2 , OH·, and O 2 −·. With electron paramagnetic resonance and fluorescent probes, it is confirmed that TPT@B 12 H 12 increases the levels of 1 O 2 , OH·, and O 2 −·. More importantly, TPT@B 12 H 12 effectively suppress the melanoma growth both in vitro and in vivo through 1 O 2 , OH·, and O 2 −· generation. This study specifically highlights the great clinical translational potential of TPT@B 12 H 12 as a CDT reagent.
论文类型:期刊论文
论文编号:10.1002/smll.202307029
学科门类:理学
文献类型:J
是否译文:
发表时间:2023-09-15
收录刊物:SCI、EI
发布期刊链接:https://onlinelibrary.wiley.com/doi/10.1002/smll.202307029
发表时间:2023-09-15

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