Applications of Boron Cluster Supramolecular Frameworks as Metal-Free Chemodynamic Therapy Agents for Melanoma
发布时间：2023-09-28
点击次数：
- 影响因子：
- 13.0
- DOI码：
- 10.1002/smll.202307029
- 发表刊物：
- Small
- 摘要：
- Chemodynamic therapy (CDT) is a highly targeted approach to treat cancer since it converts hydrogen peroxide into harmful hydroxyl radicals (OH·) through Fenton or Fenton-like reactions. However, the systemic toxicity of metal-based CDT agents has limited their clinical applications. Herein, a metal-free CDT agent: 2,4,6-tri(4-pyridyl)-1,3,5-triazine (TPT)/ [closo-B 12 H 12 ] 2− (TPT@ B 12 H 12) is reported. Compared to the traditional metal-based CDT agents, TPT@B 12 H 12 is free of metal avoiding cumulative toxicity during long-term therapy. Density functional theory (DFT) calculation revealed that TPT@B 12 H 12 decreased the activation barrier more than 3.5 times being a more effective catalyst than the Fe 2+ ion (the Fenton reaction), which decreases the barrier about twice. Mechanismly, the theory calculation indicated that both [B 12 H 12 ] −· and [TPT-H] 2+ have the capacity to decompose hydrogen into 1 O 2 , OH·, and O 2 −·. With electron paramagnetic resonance and fluorescent probes, it is confirmed that TPT@B 12 H 12 increases the levels of 1 O 2 , OH·, and O 2 −·. More importantly, TPT@B 12 H 12 effectively suppress the melanoma growth both in vitro and in vivo through 1 O 2 , OH·, and O 2 −· generation. This study specifically highlights the great clinical translational potential of TPT@B 12 H 12 as a CDT reagent.
- 论文类型：
- 期刊论文
- 论文编号：
- 10.1002/smll.202307029
- 学科门类：
- 理学
- 文献类型：
- J
- 是否译文：
- 否
- 发表时间：
- 2023-09-15
- 收录刊物：
- SCI、EI